Effect of Diclofenac on the Pharmacokinetics of Moxifloxacin in Rats

Abstract

A sensitive and specific method was developed and validated for the determination of moxifloxacin in plasma using HPLC. The effect of diclofenac (12.5, 25, 50 mg/kg) on the pharmacokinetics of orally administered moxifloxacin (40 mg/kg) in rats was investigated. Pharmacokinetic parameters of moxifloxacin were determined in rats following oral administration to rats in the presence and absence of diclofenac. The coadministration of the 2 drugs resulted in 10~29.5% decrease of the AUC and a 24.7~34% decrease of t_1/2 for moxifloxacin; T_max for moxifloxacin was 1.41~1.9-fold higher than that after the administration of moxifloxacin alone; C_max for moxifloxacin decreased by 20.5~49%, as compared to that after the administration of moxifloxacin alone. Consequently, moxifloxacin and diclofenac should be monitored closely for potential drug interactions.

Key words

moxifloxacin - diclofenac - pharmacokinetics - HPLC

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