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DOI: 10.1055/s-0033-1357652
SELECT, Selen und Prostatakrebs-Prävention − ein Blick auf die Fakten
Publication History
Publication Date:
25 June 2014 (online)
Zusammenfassung
Die 2009 veröffentlichte SELECT-Studie schien die Hoffnung zu zerstören, Selen könne chemopräventiv das Risiko für Prostatakrebs erniedrigen. Genaue Analysen zeigten jedoch die Schwäche der Studie auf. Eine neue Nachauswertung sorgt nun für Unsicherheit, doch die Publikation kann die Schwächen der Studie nicht kompensieren und zeigt in einer korrekten Auswertung auch keine signifikanten Ergebnisse. Nur in einigen a-posteriori-Berechnungen zeigten sich signifikante Ergebnisse, dies entspricht aber nicht den GCP-Richtlinien.
Summary
The 2009 publication of the results of the SELECT cancer prevention trial seemed to destroy all hopes that selenium as a chemopreventive supplement could lower the risk for prostate cancer. After analysis of the study results in detail the weaknesses of this trial became clear. Now a new publication has been published, seemingly adding new arguments, but this re-analysis suffers from the same restrictions like the first. Moreover, the only significant results have been found in a-posteriori calculations which does not comply with GCP guidelines.
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Literatur
- 1 Frankel PH et al Baseline selenium and prostate cancer risk: comments and open questions. Editorial. J Natl Cancer Inst Epub 22. Februar 2014;
- 2 Geybels MS et al Selenoprotein gene variants, toenail selenium levels, and risk of advanced prostate cancer. J Natl Cancer Inst Epub. 22. Februar 2014;
- 3 Hatfield DL, Gladyshev VN. The outcome of selenium and vitamin E cancer prevention trial (SELECT) reveals the need for better understanding the selenium biology. Molecular Interventions 2009; 9: 18-21
- 4 Klein EA et al Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Am Med Assoc 2011; 306: 1549-1556
- 5 Kristal AR et al Baseline selenium status and effects of selenium and vitamin E supplementation on prostate cancer risk. J Natl Cancer Inst Epub. 22. Februar 2014;
- 6 Lippman SM et al Effect of selenium and vitamin E on risk of prostate cancer and other cancers. The Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Am Med Assoc 2009; 301: 39-51
- 7 Mücke R et al Selenium or no selenium − that is the question in tumor patients: a new controversy. Integr Cancer Ther 2010; 9: 136-141
- 8 Stoll G. Selen, Prävention von Prostatakrebs und Diabetes − Fakten zur SELECT-Studie. Dtsch Z Onkol 2009; 41: 115-118
- 9 Tsavachidou D et al Selenium and vitamin E: Cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst 2009; 101: 306-320
- 10 Wallenberg M et al Selenium cytotoxicity in cancer. Basic Clin Pharmacol Toxicol Epub. 17. Februar 2014;