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Pharmacopsychiatry 2013; 46(07): 281-285
DOI: 10.1055/s-0033-1354407
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Antidepressant-induced Tardive Syndrome: a Retrospective Epidemiological Study

Y. Lee
1   Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
P.-Y. Lin
1   Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
Y.-Y. Chang
2   Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
M.-Y. Chong
1   Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
A. T. Cheng
3   Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
› Author Affiliations
Further Information

Publication History

received 25 May 2013
revised 13 August 2013

accepted 14 August 2013

Publication Date:
20 September 2013 (online)

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Abstract

Introduction:

The impact of using antidepressant on the occurrence of tardive syndrome is rarely studied. Here we aimed to investigate the prevalence of various types of antidepressant-induced tardive syndrome.

Methods:

This study was conducted by means of a retrospective survey. Subjects receiving antidepressant(s) for over 6 months, but no other agents that may cause involuntary movements, were consecutively recruited. Tardive syndrome was evaluated in every included subject. Possible confounding medical conditions were carefully ruled out.

Results:

Of the 158 included subjects, 22 (14.0%) were found to have at least one tardive syndrome. The prevalence of subtypes of tardive syndromes was: tardive dystonia: 10.8%, tardive dykinesia: 3.2%, tardive tremor: 1.3%, tardive parkinsonism: 1.3%, tardive tics: 1.3%, tardive sensory syndrome: 1.3%, and tardive myoclonus: 0.6%. Using serotonin-norepinephrine reuptake inhibitors and previous marital status significantly increase the risk of tardive syndrome.

Discussion:

This study showed that antide­pressants may induce various types of tardive syndrome, of which tardive dystonia is the predominant form. Clinicians should be cautious of this infrequent but distressing adverse effect when using antidepressants.

Key words

antidepressant - tardive syndrome - tardive dystonia
 

  • References

  • 1 Bressan RA, Erlandsson K, Jones HM et al. Is regionally selective D2/D3 dopamine occupancy sufficient for atypical antipsychotic effect? an in vivo quantitative [123I]epidepride SPET study of amisulpride-treated patients. Am J Psychiatry 2003; 160: 1413-1420
    CrossrefPubMedGoogle Scholar
  • 2 Fahn S, Jankovic J. The tardive syndromes phenomenology, concepts on pathophysiology and treatment, and other neuroleptic-induced syndromes. In: Principles and Practice of Movement Disorders. Churchill Livingstone press; Philadelphia: 2007. 479-518
    Google Scholar
  • 3 Jankovic J. Tardive syndromes and other drug-induced movement disorders. Clin Neuropharmacol 1995; 18: 197-214
    CrossrefPubMedGoogle Scholar
  • 4 Fernandez HH, Friedman JH. Classification and treatment of tardive syndromes. Neurologist 2003; 9: 16-27
    CrossrefPubMedGoogle Scholar
  • 5 Browne S, Roe M, Lane A et al. Quality of life in schizophrenia: relationship to sociodemographic factors, symptomatology and tardive dyskinesia. Acta Psychiatr Scand 1996; 94: 118-124
    CrossrefPubMedGoogle Scholar
  • 6 Gill HS, DeVane CL, Risch SC. Extrapyramidal symptoms associated with cyclic antidepressant treatment: a review of the literature and consolidating hypotheses. J Clin Psychopharmacol 1997; 17: 377-389
    CrossrefPubMedGoogle Scholar
  • 7 Leo RJ. Movement disorders associated with the serotonin selective reuptake inhibitors. J Clin Psychiatry 1996; 57: 449-454
    CrossrefPubMedGoogle Scholar
  • 8 Dubovsky SL, Thomas M. Tardive dyskinesia associated with fluoxetine. Psychiatr Serv 1996; 47: 991-993
    PubMedGoogle Scholar
  • 9 Botsaris SD, Sypek JM. Paroxetine and tardive dyskinesia. J Clin Psychopharmacol 1996; 16: 258-259
    CrossrefPubMedGoogle Scholar
  • 10 Birthi P, Walters C, Karandikar N. A rare case of tardive dyskinesia and akathisia induced by citalopram. Pm R 2010; 2: 973-975
    CrossrefPubMedGoogle Scholar
  • 11 Deuschle M, Mase E, Zink M. Dyskinesia during treatment with duloxetine. Pharmacopsychiatry 2006; 39: 237-238
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Yassa R, Camille Y, Belzile L. Tardive dyskinesia in the course of antidepressant therapy: a prevalence study and review of the literature. J Clin Psychopharmacol 1987; 7: 243-246
    PubMedGoogle Scholar
  • 13 Skidmore F, Reich SG. Tardive dystonia. Curr Treat Options Neurol 2005; 7: 231-236
    CrossrefPubMedGoogle Scholar
  • 14 van Harten PN, Kahn RS. Tardive dystonia. Schizophr Bull 1999; 25: 741-748
    CrossrefPubMedGoogle Scholar
  • 15 Chen PY, Lin PY, Tien SC et al. Duloxetine-related tardive dystonia and tardive dyskinesia: a case report. Gen Hosp Psychiatry 2010; 32: 646 e649-646 e611
    PubMedGoogle Scholar
  • 16 Lin CC, Lin PY, Lee Y et al. Tardive dystonia and tardive sensory syndrome related to trazodone: a case report. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1609-1610
    CrossrefPubMedGoogle Scholar
  • 17 Lee Y, Yeh WC, Chong MY et al. Venlafaxine and tardive blepharospasm: a case report. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1139-1140
    CrossrefPubMedGoogle Scholar
  • 18 Fountoulakis KN, Samara M, Siapera M et al. Tardive Tourette-like syndrome: a systematic review. Int Clin Psychopharmacol 2011; 26: 237-242
    CrossrefPubMedGoogle Scholar
  • 19 Little JT, Jankovic J. Tardive myoclonus. Mov Disord 1987; 2: 307-311
    CrossrefPubMedGoogle Scholar
  • 20 Ford B, Greene P, Fahn S. Oral and genital tardive pain syndromes. Neurology 1994; 44: 2115-2119
    CrossrefPubMedGoogle Scholar
  • 21 Chen CK, Wu JH. Improvement of risperidone-related tardive parkinsonism with a switch to aripiprazole. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 1279-1280
    CrossrefPubMedGoogle Scholar
  • 22 Stacy M, Jankovic J. Tardive tremor. Mov Disord 1992; 7: 53-57
    PubMedGoogle Scholar
  • 23 Tarsy D, Indorf G. Tardive tremor due to metoclopramide. Mov Disord 2002; 17: 620-621
    CrossrefPubMedGoogle Scholar
  • 24 Fennig S, Fennig SN, Pato M et al. Emergence of symptoms of Tourette's syndrome during fluvoxamine treatment of obsessive-compulsive disorder. Br J Psychiatry 1994; 164: 839-841
    CrossrefPubMedGoogle Scholar
  • 25 Buscombe C, Alusi SH, Kahn DA. A biopsychosocial approach to improving quality of life in tardive dystonia. J Psychiatr Pract 2010; 16: 350-357
    CrossrefPubMedGoogle Scholar
  • 26 Tarsy D, Baldessarini RJ. Epidemiology of tardive dyskinesia: is risk declining with modern antipsychotics?. Mov Disord 2006; 21: 589-598
    CrossrefPubMedGoogle Scholar
  • 27 American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision. (DSM-IV-TR). Washington, DC: American Psychiatric Association; 2000
    Google Scholar
  • 28 Chouinard G, Margolese HC. Manual for the extrapyramidal symptom rating scale (ESRS). Schizophr Res 2005; 76: 247-265
    CrossrefPubMedGoogle Scholar
  • 29 Correll CU, Schenk EM. Tardive dyskinesia and new antipsychotics. Curr Opin Psychiatry 2008; 21: 151-156
    CrossrefPubMedGoogle Scholar
  • 30 Aityanjee Aderibigbe YA, Jampala VC. et al. The current status of tardive dystonia. Biol Psychiatry 1999; 45: 715-730
    CrossrefPubMedGoogle Scholar
  • 31 Remington GJ. The Pisa syndrome: possible role for serotonin and noradrenaline. J Clin Psychopharmacol 1988; 8: 228-229
    PubMedGoogle Scholar
  • 32 Kulkarni SK, Naidu PS. Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives. Drugs Today (Barc) 2003; 39: 19-49
    CrossrefPubMedGoogle Scholar
  • 33 Madhusoodanan S, Alexeenko L, Sanders R et al. Extrapyramidal symptoms associated with antidepressants – a review of the literature and an analysis of spontaneous reports. Ann Clin Psychiatry 2010; 22: 148-156
    PubMedGoogle Scholar
  • 34 Schillevoort I, van Puijenbroek EP, de Boer A et al. Extrapyramidal syndromes associated with selective serotonin reuptake inhibitors: a case-control study using spontaneous reports. Int Clin Psychopharmacol 2002; 17: 75-79
    CrossrefPubMedGoogle Scholar
  • 35 Libov I, Miodownik C, Bersudsky Y et al. Efficacy of piracetam in the treatment of tardive dyskinesia in schizophrenic patients: a randomized, double-blind, placebo-controlled crossover study. J Clin Psychiatry 2007; 68: 1031-1037
    CrossrefPubMedGoogle Scholar
  • 36 Lerner V, Miodownik C, Kaptsan A et al. Vitamin B6 treatment for tardive dyskinesia: a randomized, double-blind, placebo-controlled, crossover study. J Clin Psychiatry 2007; 68: 1648-1654
    CrossrefPubMedGoogle Scholar