Pharmacopsychiatry 2013; 46(07): 281-285
DOI: 10.1055/s-0033-1354407
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Antidepressant-induced Tardive Syndrome: a Retrospective Epidemiological Study

Y. Lee
1   Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
P.-Y. Lin
1   Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
Y.-Y. Chang
2   Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
M.-Y. Chong
1   Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan
,
A. T. Cheng
3   Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
› Author Affiliations
Further Information

Publication History

received 25 May 2013
revised 13 August 2013

accepted 14 August 2013

Publication Date:
20 September 2013 (online)

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Abstract

Introduction:

The impact of using antidepressant on the occurrence of tardive syndrome is rarely studied. Here we aimed to investigate the prevalence of various types of antidepressant-induced tardive syndrome.

Methods:

This study was conducted by means of a retrospective survey. Subjects receiving antidepressant(s) for over 6 months, but no other agents that may cause involuntary movements, were consecutively recruited. Tardive syndrome was evaluated in every included subject. Possible confounding medical conditions were carefully ruled out.

Results:

Of the 158 included subjects, 22 (14.0%) were found to have at least one tardive syndrome. The prevalence of subtypes of tardive syndromes was: tardive dystonia: 10.8%, tardive dykinesia: 3.2%, tardive tremor: 1.3%, tardive parkinsonism: 1.3%, tardive tics: 1.3%, tardive sensory syndrome: 1.3%, and tardive myoclonus: 0.6%. Using serotonin-norepinephrine reuptake inhibitors and previous marital status significantly increase the risk of tardive syndrome.

Discussion:

This study showed that antide­pressants may induce various types of tardive syndrome, of which tardive dystonia is the predominant form. Clinicians should be cautious of this infrequent but distressing adverse effect when using antidepressants.