Abstract
Dimedone derivatives (L1–L4) with methyl substitution at the ortho, para and meta positions were synthesized and their anti-radical, photoreactive and photostability
activities were evaluated. All compounds are characterized by spectroscopic techniques
and by single crystal X ray diffraction. UV exposure experiments on pBR322 showed
inhibition of plasmid DNA fragmentation by UV radiation in a dose dependent manner.
Radical scavenging assays and ESR spectra indicate that these compounds possess antiradical
activities and do not photodegrade to form other side products as confirmed by chromatographic
analysis. They are non-cytotoxic towards human keratinocyte HaCaT cell line indicates
their potentiality in sunscreens.
Key words
DNA protection - non-cytotoxic - molecular structure - photoreactivity