Drug Res (Stuttg) 2013; 63(12): 650-656
DOI: 10.1055/s-0033-1351287
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Non-cytotoxic Dimedone Derivatives: Structure, Antiradical and UV Protective Studies

P. V. Joshi
1   Centre for Materials Characterization, National Chemical Laboratory, Pune, India
,
K. S. Mundhe
2   Dr. T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parashurambhau College, Pune, India
,
A. A. Khan
3   Institute of Bioinformatics & Biotechnology, University of Pune, Pune, India
,
R. L. Gawade
1   Centre for Materials Characterization, National Chemical Laboratory, Pune, India
,
N. R. Deshpande
2   Dr. T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parashurambhau College, Pune, India
,
R. V. Kashalkar
2   Dr. T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parashurambhau College, Pune, India
,
V. G. Puranik
1   Centre for Materials Characterization, National Chemical Laboratory, Pune, India
› Institutsangaben
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Publikationsverlauf

received 15. Mai 2013

accepted 07. Juli 2013

Publikationsdatum:
31. Juli 2013 (online)

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Abstract

Dimedone derivatives (L1–L4) with methyl substitution at the ortho, para and meta positions were synthesized and their anti-radical, photoreactive and photostability activities were evaluated. All compounds are characterized by spectroscopic techniques and by single crystal X ray diffraction. UV exposure experiments on pBR322 showed inhibition of plasmid DNA fragmentation by UV radiation in a dose dependent manner. Radical scavenging assays and ESR spectra indicate that these compounds possess antiradical activities and do not photodegrade to form other side products as confirmed by chromatographic analysis. They are non-cytotoxic towards human keratinocyte HaCaT cell line indicates their potentiality in sunscreens.

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