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Drug Res (Stuttg) 2013; 63(12): 607-613
DOI: 10.1055/s-0033-1349130
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis and Anticonvulsant and Antidepressant Activity of Some 2-(6-bromo-2,3-dioxoindolin)-N-substituted Phenylacetamide Derivatives

C. Xie
1   School of Food, Drug & Medicine Zhejiang Ocean University, Zhoushan, P. R. China
,
L.-M. Tang
1   School of Food, Drug & Medicine Zhejiang Ocean University, Zhoushan, P. R. China
,
C.-Y. Pan
1   School of Food, Drug & Medicine Zhejiang Ocean University, Zhoushan, P. R. China
,
L.-P. Guan
1   School of Food, Drug & Medicine Zhejiang Ocean University, Zhoushan, P. R. China
› Author Affiliations
Further Information

Publication History

received 04 June 2013

accepted 09 June 2013

Publication Date:
17 July 2013 (online)

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Synthesis and Anticonvulsant and Antidepressant Activity of Some 2-(6-bromo-2,3-dioxoindolin)-N-substituted Phenylacetamide DerivativesDrug Res (Stuttg) 2014; 64(07): 392-392
DOI: 10.1055/s-0034-1371870

Abstract

16 2-(6-bromo-2,3-dioxoindolin-1-yl)-N-substituted phenylacetamide derivatives were synthesized. The chemical structures of the compounds were proved by IR, 1H-NMR, 13C-NMR, Mass spectrometric data and microanalyses. The antidepressant activities of the compounds were investigated by Porsolt’s behavioural despair (the forced swimming test) in mice. 2-(6-bromo-2,3-dioxoi-ndolin-1-yl)-N-(2-fluorophenyl)acetamide(4f), 2-(6-bromo-2,3-dioxoindolin-1-yl)-N-(3-chlorophenyl)acetamide(4j), 2-(6-bromo-2,3-dioxoindolin-1-yl)-N-(4-bromophenyl)acetamide(4m) reduced 54.9–44.6% duration of immobility times at 100 mg · kg−1 dose level. Anticonvulsant activities were determined by substances pentylenetetrazloe(metrazol)(anti-PTZ) test, and neurotoxicities were determined by the rotarod toxicity test in mice. 12 synthesized compounds were found protective against PTZ at 100 mg ∙ kg−1 dose level.

Key words

2,3-dioxoindolin - phenylacetamides - anticonvulsant activity - antidepressant activity
 

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