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Synfacts 2014; 10(1): 0041
DOI: 10.1055/s-0033-1340430
DOI: 10.1055/s-0033-1340430
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
A Chiral Biaryl P,N-Ligand for Asymmetric Catalysis
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
13. Dezember 2013 (online)
Significance
The authors reported the preparation of a new chiral biaryl P,N-ligand incorporating a five-membered electron-rich heteroaromatic. This ligand is easy to prepare and an effective catalyst for the enantioselective alkynylation of imines.
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Comment
In contrast to the six-membered P,N-ligands, five-membered P,N-ligands are configurationally unstable. The authors have succeeded in preparing a configurationally stable five-membered P,N-ligand involving π-stacking interaction, which would offer a new, unexplored chemical diversity.
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