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Synfacts 2014; 10(1): 0100
DOI: 10.1055/s-0033-1340397
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Spirooxindoles Using CuFe2O4 Nanoparticles

Contributor(s):
Yasuhiro Uozumi
,
Makoto Nagaosa
Bazgir A, Hosseini G, Ghahremanzadeh R * Shahid Beheshti University, Tehran and Avicenna Research Institute, Tehran, Iran
Copper Ferrite Nanoparticles: An Efficient and Reusable Nanocatalyst for a Green One-Pot, Three-Component Synthesis of Spirooxindoles in Water.

ACS Comb. Sci. 2013;
15: 530-534
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Further Information

Publication History

Publication Date:
13 December 2013 (online)

 
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Key words

magnetic nanoparticles - cyclic 1,3-diones - activated acetonitriles - isatins - spirooxindoles

Significance

CuFe2O4 nanoparticles catalyzed the three-component coupling of cyclohexane-1,3-diones, activated acetonitriles and isatins to give the corresponding spirooxindoles (38 examples, 81–97% yield).


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Comment

In the synthesis of product A, the catalyst was recovered magnetically and reused four times (1st reuse: 90% yield, 2nd reuse: 89% yield, 3rd reuse: 88% yield, 4th reuse: 80% yield).


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