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Synfacts 2014; 10(1): 0071
DOI: 10.1055/s-0033-1340366
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Co/Ti Cooperative C(sp2)–C(sp2) Cross-Coupling Reactions

Contributor(s):
Paul Knochel
,
Andreas K. Steib
Zeng J, Liu KM, Duan XF * Beijing Normal University, P. R. of China
Selective Co/Ti Cooperatively Catalyzed Biaryl Couplings of Aryl Halides with Aryl Metal Reagents.

Org. Lett. 2013;
15: 5342-5345
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Publication History

Publication Date:
13 December 2013 (online)

 
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Key words

cobalt - titanium - cooperative catalysis

Significance

A novel method for cobalt-catalyzed cross-coupling reactions between aryl chlorides or bromides and aromatic magnesium or lithium reagents is reported by Duan and co-workers. The presence of 40 mol% of Ti(OEt)4 suppresses undesired homocoupling side-products resulting from the organometallic reagent.


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Comment

Interestingly, the reaction can also take place in the presence of a free carboxylic acid, a hydroxyl, or an amide residue. Therefore, this protocol allows an efficient arylation of highly functionalized aryl halides without protection–deprotection sequences.


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