Molecular Virology of Hepatitis E Virus

R. Prasida Holla; Imran Ahmad; Zulfazal Ahmad; Shahid Jameel

doi:10.1055/s-0033-1338110

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 2013; 33(01): 003-014
DOI: 10.1055/s-0033-1338110

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Molecular Virology of Hepatitis E Virus

R. Prasida Holla

¹Virology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

^*Both authors contributed equally to the article.

,

Imran Ahmad

¹Virology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

^*Both authors contributed equally to the article.

,

Zulfazal Ahmad

¹Virology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

,

Shahid Jameel

¹Virology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

› Author Affiliations

Abstract

Hepatitis E virus (HEV) is the causative agent of hepatitis E. It is a nonenveloped virus with a ∼7.2 kilobases positive-stranded RNA genome. The molecular virology of HEV is getting better understood with the development of replicons and in vitro infection systems, and the discovery of related viruses that infect animal species other than humans. This review focuses on the virology of HEV and updates the current knowledge on the HEV genome and its constituent proteins—ORF1, ORF2, and ORF3, and the viral life cycle.

Keywords

hepatitis E - HEV - ORF1 - ORF2 - ORF3 - RNA replication

Full Text

References

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