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Fortschr Neurol Psychiatr 2013; 81(S 01): S17-S21
DOI: 10.1055/s-0033-1335378
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Bildgebende Verfahren bei bipolaren Erkrankungen

Neuroimaging of Bipolar Disorders
A. Grunze
1   East CMHT, NTW NHS Foundation Trust, Newcastle upon Tyne, UK
,
E. Meisenzahl
2   Klinik für Psychiatrie und Psychotherapie, Ludwigs-Maximillians Universität, Műnchen
,
H. Grunze
3   Academic Psychiatry, Institute of Neuroscience, Newcastle upon Tyne, UK
› Author Affiliations
Further Information

Publication History

Publication Date:
16 May 2013 (online)

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Zusammenfassung

Sowohl in der strukturellen als auch in der funktionellen Bildgebung bei affektiven Störungen haben sich in den letzten Jahren deutliche Fortschritte ergeben. Strukturelle Veränderungen im limbischen System, präfrontalen Kortex sowie in subkortikalen Bereichen – einschließlich ihrer faszikulären Verbindungen – scheinen in den meisten, aber nicht in allen Untersuchungen mit affektiven Störungen zu korrelieren. Insbesondere bei bipolaren Störungen zeigt sich hier noch eine deutliche Varianz der Ergebnisse. Funktionelle Neuro-Imaging-Verfahren wie fMRI, PET und SPECT unterstreichen die besondere Bedeutung paralimbischer, kortikaler und subkortikaler Strukturen in der Affektregulation; allerdings steckt die Methodik dieser Untersuchungen noch in den Kinderschuhen, so dass die Reproduzierbarkeit der Ergebnisse nicht immer gegeben ist. Zusammenfassend ist jedoch abzusehen, dass mit einer weiteren Verfeinerung der Methodik der funktionellen Bildgebung auch bei affektiven, einschließlich bipolaren Störungen in Zukunft eine wachsende Bedeutung zukommen wird.

Abstract

During recent years, marked progress has been made both in structural and functional neuroimaging of affective disorders. Structural changes in the limbic system, prefrontal cortex and subcortical regions including their fascicular connections appear to correlate with affective disorders in most, but not all studies. Especially for bipolar disorder, there still is a considerable heterogeneity among the results. Functional neuroimaging (fMRI, SPECT, PET) underlines the importance of paralimbic, cortical and subcortical structures in mood regulation; however, the methodology of these studies is still in its infancy meaning that the results of these studies are not always reproducible. However, in summary it can be expected that with improving methodology functional neuroimaging will play an increasing role in affective, including bipolar, disorders in the near future.

Schlüsselwörter

Bildgebung, strukturell und funktionell - Depression - bipolare Störungen

Key words

neuroimaging, structural and functional - depression - bipolar disorders
 

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