Maternal Genotype and Gestational Diabetes

Abstract

Objective To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM).

Study Design We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations.

Results GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele.

Conclusion We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance.

Keywords

diabetes - gestational diabetes - genetics - single nucleotide polymorphisms

Prior Presentation

Preliminary findings were presented at the 30th Annual Meeting of the Society for Maternal-Fetal Medicine and at the 32nd Annual Meeting of the Society for Maternal-Fetal Medicine.

Funding

This study received support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD28684, HD28684A, HD37584, HD39373), the National Institute of Diabetes and Digestive and Kidney Diseases (DK61981, DK56350), the National Cancer Institute (CA109804–01), National Institute of Health General Clinical Research Center (RR00046), the Carolina Population Center, the UNC University Research Council and the Nutrition and Obesity Research Council (DK056350). Dr. Stuebe received support from the WRHR Career Development Center at UNC (5K12HD050113). Ms. Wise received support from T32ES0071018.

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