Indian Boswellia oder die Renaissance des Olibanums in der westlichen Welt

Zusammenfassung

Seit Jahrtausenden wird Olibanum, das Harz der Weihrauchbäume, in verschiedenen Kulturen zur Behandlung von Krankheiten, v.a. chronisch entzündlicher Art, verwendet. Bis in das 20. Jh. war Olibanum auch Bestandteil des Deutschen Arzneibuches (DAB 6 Erg.-Bd.). Kleinere, überwiegend unkontrollierte klinische Studien berichten über eine Wirksamkeit bei rheumatoider Arthritis, Kniegelenksarthrosen, Colitis ulcerosa, chronischer Kolitis, kollagener Kolitis, Morbus Crohn und Asthma bronchiale. Als Mechanismus der antientzündlichen Wirkung werden die Hemmung der 5-Lipoxygenase (und damit der Leukotrienbildung) sowie die immunmodulierende Wirkung (Hemmung verschiedener Zytokine) angesehen. Olibanum von Boswellia serrata Roxb. (Indischer Weihrauch) ist heute Bestandteil des Europäischen Arzneibuches.

Summary

Indian Boswellia and the renaissance of olibanum in the Western World Olibanum, the resin of Boswellia tree, is used in different cultures to treat a variety of diseases, especially inflammatory ones. Until the 20^th Century, olibanum was part and parcel of the German Pharmacopoeia. According to small scale but mostly uncontrolled clinical studies, frankincense has proven to be effective in treating rheumatoid arthritis, knee arthritis, ulcerative colitis, chronic colitis, collagenous colitis, Crohn's disease and asthma. The mechanism for the anti-inflammatory effect is linked to the inhibition of 5-lipoxygenase as well as immunomodulating effects (inhibition of various cytokines). Nowadays, olibanum from Boswellia serrata Roxb. (Indian frankincense) is part and parcel of the European Pharmacopoeia.

Schlüsselwörter

Boswellia-Spezies - Boswelliasäuren - Olibanum - Weihrauch - chronisch entzündliche Erkrankungen

Key words

Boswellia species - boswellic acids - olibanum - chronic inflammatory diseases - review

• Literatur

• 1 Charaka Samhita. Indien ca. 800–1000 v.Chr..
• 2 Madaus LehrbuchG.. der Biologischen Heilmittel [Nachdruck der Ausgabe Leipzig 1938].. Bd. III Hildesheim: New York: Georg Olms Verlag; 1979
• 3 Martinetz D, Lohs K, Janzen WeihrauchJ.. und Myrrhe. Stuttgart: Wiss. Verlagsges 1989;
• 4 Singh GB, Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent.. Agents Actions 1986; 18: 407-412
• 5 Ammon HPT, Mack T, Singh GB, Safayhi H.. Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata.. Planta Med 1991; 57: 203-207
• 6 Safayhi H, Sailer ER, Ammon HPT. Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.. Mol Pharmacol 1995; 47: 1212-1216
• 7 Etzel R. Special extract of Boswellia serrata (H 15) in the treatment of rheumatoid arthritis.. Phytomedicine 1996; 3: 91-94
• 8 Sander O, Herborn G, Rau R. Ist H15 (Harzextrakt von Boswellia serrata, »Weihrauch«) eine sinnvolle Ergänzung zur etablierten medikamentösen Therapie der chronischen Polyarthritis? – Ergebnisse einer doppelblinden Pilotstudie.. Z Rheumatol 1998; 57: 11-16
• 9 Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of the knee – a randomized double blind placebo controlled trial.. Phytomedicine 2003; 10: 3-7
• 10 Sengupta K, Alluri KV, Satish AR et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee.. Arthritis Res Ther 2008; 10: R85
• 11 Sengupta K, Krishnaraju AV, Vishal AA et al. Comparative efficacy and tolerability of 5-Loxin® and Aflapin® against osteoarthritis of the knee: a double blind randomized placebo controlled clinical study.. Int J Med Sci 2010; 7: 366-377
• 12 Gupta I, Gupta V, Parihar A et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.. Eur J Med Res 1998; 3: 511-514
• 13 Gupta I, Parihar A, Malhotra P et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis.. Eur J Med Res 1997; 2: 37-43
• 14 Gupta I, Parihar A, Malhotra P et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis.. Planta Med 2001; 67: 391-395
• 15 Madisch A, Miehlke S, Eichele O et al. Boswellia serrata Extrakt bei kollagener Kolitis – eine randomisierte, placebo-kontrollierte, doppelblinde Multicenterstudie [P061].. Z Gastroenterol 2005; 43: 780
• 16 Gerhardt H, Seifert F, Buvari P et al. Therapie des aktiven Morbus Crohn mit dem Boswellia- serrata-Extrakt H 15.. Z Gastroenterol 2001; 39: 11-17
• 17 Holtmeier W, Zeuzem S, Preiss J et al. Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn’s disease: good safety profile but lack of efficacy.. Inflamm Bowel Dis 2011; 17: 573-582
• 18 Ammon HP. Modulation of the immune system by Boswellia serrata extracts and boswellic acids.. Phytomedicine 2010; 17: 862-867
• 19 Quintanilla-Fend L, Shehata AM, Bettio S et al. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE).. Phytomedicine 2011; 18: 1037-1044
• 20 Ammon HP, Shehata AM. Prevention of multiple low dose streptozotocin (MLD-STZ) induced diabetes in mice by extract from gum resin of Boswellia serrata and 11-keto-â- boswellic acids.. Diabetologia 2011; 54(Suppl. 1): S184