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Semin Thromb Hemost 2013; 39(01): 094-100
DOI: 10.1055/s-0032-1331154
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Bleeding Complications in Patients with Hematologic Malignancies

Massimo Franchini
1   Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova, Italy
,
Francesco Frattini
1   Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova, Italy
,
Silvia Crestani
1   Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova, Italy
,
Carlo Bonfanti
1   Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova, Italy
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Publikationsdatum:
17. Dezember 2012 (online)

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Abstract

Abnormalities of hemostasis are frequently encountered in patients with hematologic malignancies leading to both hemorrhagic and thrombotic adverse events. The prompt recognition and management of such complications, which have a negative impact on the morbidity and mortality of these patients, represents a major challenge for hematologists. This review describes the most important changes of hemostasis associated with hemorrhage in hematologic malignancies with particular emphasis on their contributory etiologic factors, complex pathogenic mechanisms, clinical manifestations, and therapeutic strategies. In particular, platelet and acquired coagulation abnormalities, bleeding complications in acute leukemia, and hematopoietic stem cell transplantation are discussed.

Keywords

bleeding - leukemia - hematologic malignancies - therapy
 

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