Abstract
Cutaneous vascular anomalies are congenital disorders of abnormal vascular development
and growth. Infantile hemangioma is a common type of vascular anomalies characterized
by the abnormal growth of blood vessels in the early proliferative phase, followed
by the gradual spontaneous regression of the lesion in the involuting phase. Over
the past decade, significant advances have been made in our understanding of the cellular
and molecular mechanisms that control the development, growth, and regression of infantile
hemangioma. In this article, we present a comprehensive review of the current knowledge
of the pathogenesis of hemangioma as well as promising research horizons and implications
for new therapeutic advances.
Keywords
infantile hemangioma - pathogenesis - vascular anomalies - vascular tumors
