Endomikroskopie

Kernaussagen

Prinzip

• Die Endomikroskopie stellt eine neuartige Technologie dar, die erstmals die mikroskopische Betrachtung von Gewebe auf zellulärer Ebene während der laufenden endoskopischen Untersuchung erlaubt.

• Damit können Biopsien gezielt entnommen werden an Stellen, die eine auffällige endomikroskopische Struktur aufweisen, oder die Läsion kann unmittelbar aufgrund der intravital-mikroskopischen Diagnose endoskopisch therapiert werden.

• An Stellen mit normaler Schleimhautarchitektur in der „optischen Biopsie“ sind keine Gewebeentnahmen nötig.

Einsatzgebiete

• Die Endomikroskopie ist besonders nützlich zur Detektion prämaligner oder maligner Veränderungen in einem frühen Stadium bei Patienten mit erhöhtem Krebsrisiko. Hierzu gehören insbesondere Patienten mit Barrett-Ösophagus, Präkanzerosen des Magens oder mit lang bestehender Colitis ulcerosa.

• Die kathetergeführte Endomikroskopie ist auch zur Beurteilung von Gallengangsveränderungen geeignet.

• Durch die funktionelle und molekulare Bildgebung mikroskopischer dynamischer Prozesse in ihrer natürlichen Umgebung öffnen sich für die klinische Forschung und damit für unser Verständnis der Pathophysiologie neue Horizonte.

• Literatur

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