Lymphocytic Interstitial Pneumonia and Other Benign Lymphoid Disorders

Abstract

Nonneoplastic pulmonary lymphoid disorders consist of a complex spectrum of diseases for pathologists and pulmonologists alike. Advances in our understanding of these disorders in recent years have led to revisions in the classification scheme. This review summarizes the clinicoradiological and pathological features of several benign pulmonary lymphoid disorders as well as the current knowledge regarding their pathogenesis. The disorders discussed include lymphocytic interstitial pneumonitis, follicular bronchiolitis, nodular lymphoid hyperplasia, inflammatory pseudotumor, Castleman disease, immunoglobulin G4–related disease in the lung, and posttransplant lymphoproliferative disease.

Keywords

lymphocytic interstitial pneumonia - pulmonary lymphoid disorders - pseudolymphoma

• References

• 1 Ferry JA. Angioimmunoblastic T-cell lymphoma. Adv Anat Pathol 2002; 9 (5) 273-279
• 2 Lachenal F, Berger F, Ghesquières H , et al. Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients. Medicine (Baltimore) 2007; 86 (5) 282-292
• 3 Katzenstein AL, Doxtader E, Narendra S. Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surg Pathol 2010; 34 (12) e35-e48
• 4 Carrington B, Liebow AA. Lymphocytic interstitial pneumonia [abstract]. Am J Pathol 1966; 48: 36
• 5 Liebow AA, Carrington CB. The interstitial pneumonias. In: Simon M, Potchen EJ, Lemay M, , eds. Frontiers in Pulmonary Radiology. New York: Grune & Stratton; 1969: 101-141
• 6 Herbert A, Walters MT, Cawley MI, Godfrey RC. Lymphocytic interstitial pneumonia identified as lymphoma of mucosa associated lymphoid tissue. J Pathol 1985; 146 (2) 129-138
• 7 Schuurman HJ, Gooszen HC, Tan IW, Kluin PM, Wagenaar SS, van Unnik JA. Low-grade lymphoma of immature T-cell phenotype in a case of lymphocytic interstitial pneumonia and Sjögren's syndrome. Histopathology 1987; 11 (11) 1193-1204
• 8 American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002; 165 (2) 277-304
• 9 Nicholson AG. Classification of idiopathic interstitial pneumonias: making sense of the alphabet soup. Histopathology 2002; 41 (5) 381-391
• 10 Morris JC, Rosen MJ, Marchevsky A, Teirstein AS. Lymphocytic interstitial pneumonia in patients at risk for the acquired immune deficiency syndrome. Chest 1987; 91 (1) 63-67
• 11 Oldham SA, Castillo M, Jacobson FL, Mones JM, Saldana MJ. HIV-associated lymphocytic interstitial pneumonia: radiologic manifestations and pathologic correlation. Radiology 1989; 170 (1 Pt 1) 83-87
• 12 Arish N, Eldor R, Fellig Y , et al. Lymphocytic interstitial pneumonia associated with common variable immunodeficiency resolved with intravenous immunoglobulins. Thorax 2006; 61 (12) 1096-1097
• 13 Houghton KM, Cabral DA, Petty RE, Tucker LB. Primary Sjögren's syndrome in dizygotic adolescent twins: one case with lymphocytic interstitial pneumonia. J Rheumatol 2005; 32 (8) 1603-1606
• 14 Koss MN, Hochholzer L, Langloss JM, Wehunt WD, Lazarus AA. Lymphoid interstitial pneumonia: clinicopathological and immunopathological findings in 18 cases. Pathology 1987; 19 (2) 178-185
• 15 Dicicco BS, Anderson G. Lymphocytic interstitial pneumonitis following Legionnaire's pneumonia. Chest 1994; 105 (1) 325
• 16 Chamberlain DW, Hyland RH, Ross DJ. Diphenylhydantoin-induced lymphocytic interstitial pneumonia. Chest 1986; 90 (3) 458-460
• 17 Setoguchi Y, Takahashi S, Nukiwa T, Kira S. Detection of human T-cell lymphotropic virus type I-related antibodies in patients with lymphocytic interstitial pneumonia. Am Rev Respir Dis 1991; 144 (6) 1361-1365
• 18 Barberà JA, Hayashi S, Hegele RG, Hogg JC. Detection of Epstein-Barr virus in lymphocytic interstitial pneumonia by in situ hybridization. Am Rev Respir Dis 1992; 145 (4 Pt 1) 940-946
• 19 Amorosa JK, Miller RW, Laraya-Cuasay L , et al. Bronchiectasis in children with lymphocytic interstitial pneumonia and acquired immune deficiency syndrome. Plain film and CT observations. Pediatr Radiol 1992; 22 (8) 603-606 , discussion 606–607
• 20 Katzenstein AL , ed. Primary Lymphoid Lung Lesions. 4th ed. Philadelphia, PA: Saunders Elsevier; 2006: 237-257
• 21 Swigris JJ, Berry GJ, Raffin TA, Kuschner WG. Lymphoid interstitial pneumonia: a narrative review. Chest 2002; 122 (6) 2150-2164
• 22 Guinee Jr DG. Update on nonneoplastic pulmonary lymphoproliferative disorders and related entities. Arch Pathol Lab Med 2010; 134 (5) 691-701
• 23 Hudnall SD, Betancourt E, Barnhart E, Patel J. Comparative flow immunophenotypic features of the inflammatory infiltrates of Hodgkin lymphoma and lymphoid hyperplasia. Cytometry B Clin Cytom 2008; 74 (1) 1-8
• 24 Tashiro K, Ohshima K, Suzumiya J , et al. Clonality of primary pulmonary lymphoproliferative disorders; using in situ hybridization and polymerase chain reaction for immunoglobulin. Leuk Lymphoma 1999; 36 (1–2) 157-167
• 25 Liebow AA, Carrington CB. Diffuse pulmonary lymphoreticular infiltrations associated with dysproteinemia. Med Clin North Am 1973; 57 (3) 809-843
• 26 Bégueret H, Vergier B, Parrens M , et al. Primary Lung Small B-Cell Lymphoma versus Lymphoid Hyperplasia: Evaluation of Diagnostic Criteria in 26 Cases. Am J Surg Pathol 2002; 26 (1) 76-81
• 27 Nicholson AG. Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung. Semin Respir Crit Care Med 2001; 22 (4) 409-422
• 28 Kurosu K, Yumoto N, Rom WN , et al. Oligoclonal T cell expansions in pulmonary lymphoproliferative disorders: demonstration of the frequent occurrence of oligoclonal T cells in human immunodeficiency virus-related lymphoid interstitial pneumonia. Am J Respir Crit Care Med 2002; 165 (2) 254-259
• 29 Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988; 9 (3) 467-471
• 30 Grieco MH, Chinoy-Acharya P. Lymphocytic interstitial pneumonia associated with the acquired immune deficiency syndrome. Am Rev Respir Dis 1985; 131 (6) 952-955
• 31 Johkoh T, Müller NL, Pickford HA , et al. Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology 1999; 212 (2) 567-572
• 32 Strimlan CV, Rosenow III EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonitis. Review of 13 cases. Ann Intern Med 1978; 88 (5) 616-621
• 33 Pitt J. Lymphocytic interstitial pneumonia. Pediatr Clin North Am 1991; 38 (1) 89-95
• 34 Honda O, Johkoh T, Ichikado K , et al. Differential diagnosis of lymphocytic interstitial pneumonia and malignant lymphoma on high-resolution CT. AJR Am J Roentgenol 1999; 173 (1) 71-74
• 35 Ichikawa Y, Kinoshita M, Koga T, Oizumi K, Fujimoto K, Hayabuchi N. Lung cyst formation in lymphocytic interstitial pneumonia: CT features. J Comput Assist Tomogr 1994; 18 (5) 745-748
• 36 Tokuyasu H, Watanabe E, Okazaki R , et al. Sjögren's syndrome with multiple bullae caused by lymphocytic interstitial pneumonia. Lung 2007; 185 (3) 187-188
• 37 Sumikawa H, Johkoh T, Ichikado K , et al. Usual interstitial pneumonia and chronic idiopathic interstitial pneumonia: analysis of CT appearance in 92 patients. Radiology 2006; 241 (1) 258-266
• 38 Ripamonti D, Rizzi M, Maggiolo F, Arici C, Suter F. Resolution of lymphocytic interstitial pneumonia in a human immunodeficiency virus-infected adult following the start of highly active antiretroviral therapy. Scand J Infect Dis 2003; 35 (5) 348-351
• 39 Dufour V, Wislez M, Bergot E, Mayaud C, Cadranel J. Improvement of symptomatic human immunodeficiency virus-related lymphoid interstitial pneumonia in patients receiving highly active antiretroviral therapy. Clin Infect Dis 2003; 36 (10) e127-e130
• 40 Popa V. Lymphocytic interstitial pneumonia of common variable immunodeficiency. Ann Allergy 1988; 60 (3) 203-206
• 41 Banerjee D, Ahmad D. Malignant lymphoma complicating lymphocytic interstitial pneumonia: a monoclonal B-cell neoplasm arising in a polyclonal lymphoproliferative disorder. Hum Pathol 1982; 13 (8) 780-782
• 42 Kradin RL, Young RH, Kradin LA, Mark EJ. Immunoblastic lymphoma arising in chronic lymphoid hyperplasia of the pulmonary interstitium. Cancer 1982; 50 (7) 1339-1343
• 43 Ryu JH. Classification and approach to bronchiolar diseases. Curr Opin Pulm Med 2006; 12 (2) 145-151
• 44 Ryu JH, Myers JL, Swensen SJ. Bronchiolar disorders. Am J Respir Crit Care Med 2003; 168 (11) 1277-1292
• 45 Aerni MR, Vassallo R, Myers JL, Lindell RM, Ryu JH. Follicular bronchiolitis in surgical lung biopsies: clinical implications in 12 patients. Respir Med 2008; 102 (2) 307-312
• 46 Travis WD, Galvin JR. Non-neoplastic pulmonary lymphoid lesions. Thorax 2001; 56 (12) 964-971
• 47 Deheinzelin D, Capelozzi VL, Kairalla RA, Barbas Filho JV, Saldiva PH, de Carvalho CR. Interstitial lung disease in primary Sjögren's syndrome. Clinical-pathological evaluation and response to treatment. Am J Respir Crit Care Med 1996; 154 (3 Pt 1) 794-799
• 48 Exley CM, Suvarna SK, Matthews S. Follicular bronchiolitis as a presentation of HIV. Clin Radiol 2006; 61 (8) 710-713
• 49 Fortoul TI, Cano-Valle F, Oliva E, Barrios R. Follicular bronchiolitis in association with connective tissue diseases. Lung 1985; 163 (5) 305-314
• 50 Hayakawa H, Sato A, Imokawa S, Toyoshima M, Chida K, Iwata M. Bronchiolar disease in rheumatoid arthritis. Am J Respir Crit Care Med 1996; 154 (5) 1531-1536
• 51 Romero S, Barroso E, Gil J, Aranda I, Alonso S, Garcia-Pachon E. Follicular bronchiolitis: clinical and pathologic findings in six patients. Lung 2003; 181 (6) 309-319
• 52 Sato A, Hayakawa H, Uchiyama H, Chida K. Cellular distribution of bronchus-associated lymphoid tissue in rheumatoid arthritis. Am J Respir Crit Care Med 1996; 154 (6 Pt 1) 1903-1907
• 53 Yousem SA, Colby TV, Carrington CB. Follicular bronchitis/bronchiolitis. Hum Pathol 1985; 16 (7) 700-706
• 54 Visscher DW, Myers JL. Bronchiolitis: the pathologist's perspective. Proc Am Thorac Soc 2006; 3 (1) 41-47
• 55 Howling SJ, Hansell DM, Wells AU, Nicholson AG, Flint JD, Müller NL. Follicular bronchiolitis: thin-section CT and histologic findings. Radiology 1999; 212 (3) 637-642
• 56 Lynch DA. Imaging of small airways disease and chronic obstructive pulmonary disease. Clin Chest Med 2008; 29 (1) 165-179 , vii
• 57 Kradin RL, Mark EJ. Benign lymphoid disorders of the lung, with a theory regarding their development. Hum Pathol 1983; 14 (10) 857-867
• 58 Saltzstein SL. Pulmonary malignant lymphomas and pseudolymphomas: classification, therapy, and prognosis. Cancer 1963; 16: 928-955
• 59 Abbondanzo SL, Rush W, Bijwaard KE, Koss MN. Nodular lymphoid hyperplasia of the lung: a clinicopathologic study of 14 cases. Am J Surg Pathol 2000; 24 (4) 587-597
• 60 Yi E, Aubry MC. Pulmonary pseudoneoplasms. Arch Pathol Lab Med 2010; 134 (3) 417-426
• 61 Song MK, Seol YM, Park YE , et al. Pulmonary nodular lymphoid hyperplasia associated with Sjögren's syndrome. Korean J Intern Med 2007; 22 (3) 192-196
• 62 Koss MN. Pulmonary lymphoid disorders. Semin Diagn Pathol 1995; 12 (2) 158-171
• 63 Kawahara K, Shiraishi T, Okabayashi K , et al. Nodular lymphoid hyperplasia in the lung. Thorac Cardiovasc Surg 1996; 44 (4) 210-212
• 64 Kajiwara S, Sakai S, Soeda H , et al. Multifocal nodular lymphoid hyperplasia of the lung. J Thorac Imaging 2005; 20 (3) 239-241
• 65 Miyoshi S, Hamada H, Katayama H , et al. A case of pulmonary nodular lymphoid hyperplasia with a resected cavity, followed by spontaneous regression of the remaining lesions. Intern Med 2010; 49 (15) 1617-1621
• 66 Karube Y, Chida M, Honma K, Araki O, Kobayashi S, Miyoshi S. Nodular lymphoid hyperplasia: rare case of lymphoproliferative disease in the lung. Gen Thorac Cardiovasc Surg 2009; 57 (6) 324-327
• 67 Coffin CM, Dehner LP, Meis-Kindblom JM. Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: an historical review with differential diagnostic considerations. Semin Diagn Pathol 1998; 15 (2) 102-110
• 68 Cerfolio RJ, Allen MS, Nascimento AG , et al. Inflammatory pseudotumors of the lung. Ann Thorac Surg 1999; 67 (4) 933-936
• 69 Alexiou C, Obuszko Z, Beggs D, Morgan WE. Inflammatory pseudotumors of the lung. Ann Thorac Surg 1998; 66 (3) 948-950
• 70 Sakurai H, Hasegawa T, Watanabe S, Suzuki K, Asamura H, Tsuchiya R. Inflammatory myofibroblastic tumor of the lung. Eur J Cardiothorac Surg 2004; 25 (2) 155-159
• 71 Dehner LP. Inflammatory myofibroblastic tumor: the continued definition of one type of so-called inflammatory pseudotumor. Am J Surg Pathol 2004; 28 (12) 1652-1654
• 72 Kovach SJ, Fischer AC, Katzman PJ , et al. Inflammatory myofibroblastic tumors. J Surg Oncol 2006; 94 (5) 385-391
• 73 Hosler GA, Steinberg DM, Sheth S, Hamper UM, Erozan YS, Ali SZ. Inflammatory pseudotumor: a diagnostic dilemma in cytopathology. Diagn Cytopathol 2004; 31 (4) 267-270
• 74 Kim TS, Han J, Kim GY, Lee KS, Kim H, Kim J. Pulmonary inflammatory pseudotumor (inflammatory myofibroblastic tumor): CT features with pathologic correlation. J Comput Assist Tomogr 2005; 29 (5) 633-639
• 75 Mondello B, Lentini S, Barone M , et al. Surgical management of pulmonary inflammatory pseudotumors: a single center experience. J Cardiothorac Surg 2011; 6: 18
• 76 Calderazzo M, Gallelli A, Barbieri V , et al. Inflammatory pseudotumour of the lung presenting as an airway obstructive syndrome. Respir Med 1997; 91 (6) 381-384
• 77 Huellner MW, Schwizer B, Burger I , et al. Inflammatory pseudotumor of the lung with high FDG uptake. Clin Nucl Med 2010; 35 (9) 722-723
• 78 Janik JS, Janik JP, Lovell MA, Hendrickson RJ, Bensard DD, Greffe BS. Recurrent inflammatory pseudotumors in children. J Pediatr Surg 2003; 38 (10) 1491-1495
• 79 Chen CH, Huang WC, Liu HC, Chen CH, Chen TY. Surgical outcome of inflammatory pseudotumor in the lung. Thorac Cardiovasc Surg 2008; 56 (4) 214-216
• 80 Fabre D, Fadel E, Singhal S , et al. Complete resection of pulmonary inflammatory pseudotumors has excellent long-term prognosis. J Thorac Cardiovasc Surg 2009; 137 (2) 435-440
• 81 Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer 1956; 9 (4) 822-830
• 82 Casper C. The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol 2005; 129 (1) 3-17
• 83 Cronin DMP, Warnke RA. Castleman disease: an update on classification and the spectrum of associated lesions. Adv Anat Pathol 2009; 16 (4) 236-246
• 84 Herrada J, Cabanillas F, Rice L, Manning J, Pugh W. The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med 1998; 128 (8) 657-662
• 85 Bull TM, Cool CD, Serls AE , et al. Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8. Eur Respir J 2003; 22 (3) 403-407
• 86 Hillier JC, Shaw P, Miller RF , et al. Imaging features of multicentric Castleman's disease in HIV infection. Clin Radiol 2004; 59 (7) 596-601
• 87 Du MQ, Liu H, Diss TC , et al. Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood 2001; 97 (7) 2130-2136
• 88 Dupin N, Diss TL, Kellam P , et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood 2000; 95 (4) 1406-1412
• 89 Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972; 29 (3) 670-683
• 90 McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA. Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation. Radiology 1998; 209 (1) 221-228
• 91 Barrie JR, English JC, Müller N. Castleman's disease of the lung: radiographic, high-resolution CT, and pathologic findings. AJR Am J Roentgenol 1996; 166 (5) 1055-1056
• 92 Dispenzieri A, Gertz MA. Treatment of Castleman's disease. Curr Treat Options Oncol 2005; 6 (3) 255-266
• 93 Gaba AR, Stein RS, Sweet DL, Variakojis D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol 1978; 69 (1) 86-90
• 94 Fazakas A, Csire M, Berencsi G , et al. Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection—a possible relationship. Leuk Lymphoma 2009; 50 (10) 1661-1665
• 95 Johkoh T, Müller NL, Ichikado K , et al. Intrathoracic multicentric Castleman disease: CT findings in 12 patients. Radiology 1998; 209 (2) 477-481
• 96 van Rhee F, Fayad L, Voorhees P , et al. Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman's disease. J Clin Oncol 2010; 28 (23) 3701-3708
• 97 Bandera B, Ainsworth C, Shikle J, Rupard E, Roach M. Treatment of unicentric Castleman disease with neoadjuvant rituximab. Chest 2010; 138 (5) 1239-1241
• 98 Zen Y, Nakanuma Y. IgG4-related disease: a cross-sectional study of 114 cases. Am J Surg Pathol 2010; 34 (12) 1812-1819
• 99 Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol 2008; 14 (25) 3948-3955
• 100 Hamano H, Kawa S, Horiuchi A , et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001; 344 (10) 732-738
• 101 Zen Y, Nakanuma Y. Pathogenesis of IgG4-related disease. Curr Opin Rheumatol 2011; 23 (1) 114-118
• 102 Shrestha B, Sekiguchi H, Colby TV , et al. Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis: report of 6 and 12 cases with similar histopathology. Am J Surg Pathol 2009; 33 (10) 1450-1462
• 103 Inoue D, Zen Y, Abo H , et al. Immunoglobulin G4-related lung disease: CT findings with pathologic correlations. Radiology 2009; 251 (1) 260-270
• 104 Yamashita K, Haga H, Kobashi Y, Miyagawa-Hayashino A, Yoshizawa A, Manabe T. Lung involvement in IgG4-related lymphoplasmacytic vasculitis and interstitial fibrosis: report of 3 cases and review of the literature. Am J Surg Pathol 2008; 32 (11) 1620-1626
• 105 Smyrk TC. Pathological features of IgG4-related sclerosing disease. Curr Opin Rheumatol 2011; 23 (1) 74-79
• 106 Ryu JH, Sekiguchi H, Yi ES. Pulmonary manifestations of immunoglobulin G4-related sclerosing disease. Eur Respir J 2012; 39 (1) 180-186
• 107 Zen Y, Kitagawa S, Minato H , et al. IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung. Hum Pathol 2005; 36 (7) 710-717
• 108 Takato H, Yasui M, Ichikawa Y , et al. Nonspecific interstitial pneumonia with abundant IgG4-positive cells infiltration, which was thought as pulmonary involvement of IgG4-related autoimmune disease. Intern Med 2008; 47 (4) 291-294
• 109 Hirano K, Kawabe T, Komatsu Y , et al. High-rate pulmonary involvement in autoimmune pancreatitis. Intern Med J 2006; 36 (1) 58-61
• 110 Duvic C, Desrame J, Lévêque C, Nedelec G. Retroperitoneal fibrosis, sclerosing pancreatitis and bronchiolitis obliterans with organizing pneumonia. Nephrol Dial Transplant 2004; 19 (9) 2397-2399
• 111 Hamano H, Arakura N, Muraki T, Ozaki Y, Kiyosawa K, Kawa S. Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis. J Gastroenterol 2006; 41 (12) 1197-1205
• 112 Deheragoda MG, Church NI, Rodriguez-Justo M , et al. The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis. Clin Gastroenterol Hepatol 2007; 5 (10) 1229-1234
• 113 Khosroshahi A, Stone JH. A clinical overview of IgG4-related systemic disease. Curr Opin Rheumatol 2011; 23 (1) 57-66
• 114 Zen Y, Inoue D, Kitao A , et al. IgG4-related lung and pleural disease: a clinicopathologic study of 21 cases. Am J Surg Pathol 2009; 33 (12) 1886-1893
• 115 Kobayashi H, Shimokawaji T, Kanoh S, Motoyoshi K, Aida S. IgG4-positive pulmonary disease. J Thorac Imaging 2007; 22 (4) 360-362
• 116 Dhobale S, Bedetti C, Killian P , et al. IgG4 related sclerosing disease with multiple organ involvements and response to corticosteroid treatment. J Clin Rheumatol 2009; 15 (7) 354-357
• 117 Khosroshahi A, Stone JH. Treatment approaches to IgG4-related systemic disease. Curr Opin Rheumatol 2011; 23 (1) 67-71
• 118 Khan ML, Colby TV, Viggiano RW, Fonseca R. Treatment with bortezomib of a patient having hyper IgG4 disease. Clin Lymphoma Myeloma Leuk 2010; 10 (3) 217-219
• 119 Parker A, Bowles K, Bradley JA , et al; Haemato-oncology Task Force of the British Committee for Standards in Haematology and British Transplantation Society. Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines. Br J Haematol 2010; 149 (5) 675-692
• 120 Dierickx D, Tousseyn T, De Wolf-Peeters C, Pirenne J, Verhoef G. Management of posttransplant lymphoproliferative disorders following solid organ transplant: an update. Leuk Lymphoma 2011; 52 (6) 950-961
• 121 Bakker NA, van Imhoff GW, Verschuuren EA , et al. Early onset post-transplant lymphoproliferative disease is associated with allograft localization. Clin Transplant 2005; 19 (3) 327-334
• 122 Krams SM, Martinez OM. Epstein-Barr virus, rapamycin, and host immune responses. Curr Opin Organ Transplant 2008; 13 (6) 563-568
• 123 Nourse JP, Jones K, Gandhi MK. Epstein-Barr Virus-related post-transplant lymphoproliferative disorders: pathogenetic insights for targeted therapy. Am J Transplant 2011; 11 (5) 888-895
• 124 Nalesnik MA. The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach. Transpl Infect Dis 2001; 3 (2) 88-96
• 125 Schubert S, Abdul-Khaliq H, Lehmkuhl HB , et al. Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients. Pediatr Transplant 2009; 13 (1) 54-62
• 126 Bakker NA, van Imhoff GW, Verschuuren EAM, van Son WJ. Presentation and early detection of post-transplant lymphoproliferative disorder after solid organ transplantation. Transpl Int 2007; 20 (3) 207-218
• 127 Borhani AA, Hosseinzadeh K, Almusa O, Furlan A, Nalesnik M. Imaging of posttransplantation lymphoproliferative disorder after solid organ transplantation. Radiographics 2009; 29 (4) 981-1000 , discussion 1000–1002
• 128 Scarsbrook AF, Warakaulle DR, Dattani M, Traill Z. Post-transplantation lymphoproliferative disorder: the spectrum of imaging appearances. Clin Radiol 2005; 60 (1) 47-55
• 129 Parker A, Bowles K, Bradley JA , et al; Haemato-oncology Task Force of the British Committee for Standards in Haematology and British Transplantation Society. Management of post-transplant lymphoproliferative disorder in adult solid organ transplant recipients - BCSH and BTS Guidelines. Br J Haematol 2010; 149 (5) 693-705