Am J Perinatol 2013; 30(03): 185-190
DOI: 10.1055/s-0032-1322517
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Impact of Tobacco Use on Preterm Premature Rupture of the Membranes

Robert L. Andres
1   Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah
,
Yuan Zhao
2   Department of Obstetrics and Gynecology, The George Washington University Biostatistics Center, Washington, DC
,
Mark A. Klebanoff
3   Eunice Kennedy Shriver National Institute for Child Health and Human Development, Bethesda, Maryland
,
John C. Hauth
4   Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama
,
Steve N. Caritis
5   Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania
,
J. Christopher Carey
6   Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, Oklahoma
,
Ronald J. Wapner
7   Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania
,
Jay D. Iams
8   Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio
,
Kenneth J. Leveno
9   Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas
,
Menachem Miodovnik
10   Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio
,
Baha Sibai
11   Department of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee
,
J. Peter Van Dorsten
12   Department of Obstetrics and Gynecology, Medical University of South Carolina, South Carolina
,
Mitchell P. Dombrowski
13   Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan
,
Mary J. O'Sullivan
14   Department of Obstetrics and Gynecology, University of Miami, Miami, Florida
,
Oded Langer
15   Department of Obstetrics and Gynecology, University of Texas at San Antonio, Texas
,
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network › Author Affiliations
Further Information

Publication History

29 February 2012

31 March 2012

Publication Date:
28 August 2012 (online)

Abstract

Objective To determine if tobacco use increases the incidence of preterm premature rupture of the membranes (pPROM) or alters perinatal outcomes after pPROM.

Study Design This is a secondary analysis of the databases of three completed Eunice Kennedy Shriver National Institute of Child Health and Human Development–supported Maternal Fetal Medicine Units Network studies. Self-reported tobacco exposure data was obtained. Its relationship with the incidence of pPROM and associated neonatal outcome measures were assessed.

Results There was no difference in the incidence of pPROM when comparing nonsmokers to those using tobacco. Although a trend was seen between the incidence of pPROM and the amount smoked, this did not reach statistical significance. Among the patients with pPROM, the use of tobacco was not associated with an increase in perinatal morbidity.

Conclusion Our data do not support a significant relationship between tobacco use and pPROM.

Note

Presented at the Annual Meeting of the Society for Maternal-Fetal Medicine, New Orleans, Louisiana, February 2 to 7, 2004.


 
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