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Synfacts 2013; 9(2): 0195
DOI: 10.1055/s-0032-1318067
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Diarylethynyl Methanes via a Multicomponent Coupling

Contributor(s):
Paul Knochel
,
Christoph Sämann
Gianino JB, Ashfeld BL * University of Notre Dame, USA
Titanocene-Catalyzed Multicomponent Coupling Approach to Diarylethynyl Methanes.

J. Am. Chem. Soc. 2012;
134: 18217-18220
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Further Information

Publication History

Publication Date:
18 January 2013 (online)

 
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Key words

diarylethynyl arenes - multicomponent coupling - titanocene

Significance

A straightforward synthesis of di­arylethynyl methanes via a titanocene-catalyzed multicomponent coupling has been disclosed. This rapid and divergent reaction furnishes the corresponding products in good to almost quantitative yield.


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Comment

The reported reaction shows a high degree of modularity and convergency in the rapid assembly of complex target molecules. Furthermore, the authors could apply the new protocol to the synthesis of a natural product.


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