Silylation of Alcohol Derivatives with 1,2-Disilanes Catalyzed by Au/TiO₂

Key words

gold nanoparticles - titanium dioxide - 1,2-disilanes - alcohols

Significance

Gold nanoparticles supported on titanium dioxide (Au/TiO₂) catalyzed the silylation of water and primary, secondary, and tertiary aliphatic alcohols with 1,2-disilanes via Si–Si bond cleavage to give the corresponding silyl ethers in up to >99% yield (eq. 1). When tertiary benzylic alcohols were used for the reaction, the reduction proceeded to afford the corresponding alkanes as the major products (eq. 2).

 

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Comment

The authors previously reported the oxidative cycloaddition of 1,1,3,3-tetramethyldi­siloxane to alkynes catalyzed by Au/TiO₂ (J. Am. Chem. Soc. 2011, 133, 10426). The catalytic activity of Au/TiO₂ for the silylation of water was superior to that of gold nanoparticles supported on other supports such as aluminum oxide (Al₂O₃) and zinc oxide (ZnO).

 

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