Fluorination of Nickel(II)–Aryl Complexes with [18F]Fluoride
Nickel-Mediated Oxidative Fluorination for PET with Aqueous [18F]Fluoride.
J. Am. Chem. Soc. 2012;
17 December 2012 (online)
The authors report a one-step oxidative fluorination of arylnickel complexes which enables a straight-forward and practical 18F late-stage fluorination of molecules. Therefore, 18F-labeled substances of high specific activity for PET imaging can be synthesized.
As the protocol can be performed using aqueous fluoride solutions, extensive drying procedures of fluoride, which are typical for radiochemistry, are not required. Furthermore, direct use of aqueous fluoride solutions increases the yield and prevents radioactive decay.