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Planta Med 2012; 78(15): 1661-1666
DOI: 10.1055/s-0032-1315260
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Five New 3,4-Seco-Lanostane-type Triterpenoids with Antiproliferative Activity in Human Leukemia Cells Isolated from the Roots of Kadsura coccinea

Nan Wang
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Zhan-lin Li
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Dan-dan Song
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
,
Wei Li
3   Department of Pharmacognosy, Toho University, Funabashi, Chiba, Japan
,
Yue-hu Pei
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
,
Yong-kui Jing
4   Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
,
Hui-ming Hua
1   Key Laboratory of Structure-Based Drug Design & Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang, PR China
2   School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, PR China
› Author Affiliations
Further Information

Publication History

received 31 March 2012
revised 08 July 2012

accepted 23 July 2012

Publication Date:
04 September 2012 (online)

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Abstract

Five new 3,4-seco-lanostane-type triterpenoids, seco-coccinic acids G–K (1–5), and a known compound, seco-coccinic F, were isolated from the roots of Kadsura coccinea (Lem.) A. C. Sm. Their structures were elucidated by spectroscopic methods, including 2D-NMR and HR-MS techniques. The cell growth inhibitory effects of these compounds were assayed in human leukemia HL-60 cells, and it was found that 1, 5, and 6 showed antiproliferative effects with GI50 values of 28.4, 15.2, and 16.6 µM, respectively.

Key words

Kadsura coccinea - Schizandraceae - triterpenoid - antiproliferative activity - leukemia HL-60

Supporting Information

 

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