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Planta Med 2012; 78(15): 1698-1701
DOI: 10.1055/s-0032-1315255
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Incomptines C and D, Two Heliangolides from Decachaeta incompta and Their Antiprotozoal Activity

Elihú Bautista
1   Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México City, México
,
Fernando Calzada
2   Unidad de Investigación Médica en Farmacología. UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México City, México
,
Lilian Yepez-Mulia
3   Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México City, México
,
Marco Chavez-Soto
2   Unidad de Investigación Médica en Farmacología. UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México City, México
,
Alfredo Ortega
1   Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México City, México
› Author Affiliations
Further Information

Publication History

received 16 February 2012
revised 22 June 2012

accepted 23 July 2012

Publication Date:
04 September 2012 (online)

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Abstract

Two new heliangolides, incomptines C (3) and D (4), were isolated from the leaves of Decachaeta incompta. The structures were established by spectroscopic methods and confirmed by X-ray crystallography. The antiprotozoal activity of incomptines C and D was evaluated. Additionally, the chromatographic profile of the leaves and roots extracts were compared to identify incomptines A–D (1–4) in each extract.

Key words

Asteraceae - Decachaeta incompta - Giardia lamblia - Entamoeba histolytica - heliangolides - antiprotozoal activity

Supporting Information

 

  • References

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