Planta Med 2012; 78(12): 1357-1362
DOI: 10.1055/s-0032-1315001
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Isoflavonoids from Ficus benjamina and Their Inhibitory Activity on BACE1

Jingqiu Dai
1   Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA
,
Dai Shen
2   Kenyon College, Gambier, Ohio, USA
,
Wesley Y. Yoshida
1   Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA
,
Stephen M. Parrish
1   Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA
,
Philip G. Williams
1   Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA
3   University of Hawaii Cancer Center, Honolulu, Hawaii, USA
› Author Affiliations
Further Information

Publication History

received 11 October 2011
revised 07 June 2012

accepted 08 June 2012

Publication Date:
04 July 2012 (online)

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Abstract

Examination of an active extract of the fruit of Ficus benjamina var. nuda (Miq.) Barrett has led to the isolation of six new isoflavones and two coumarano-chroman-4-ones, along with fifteen known compounds. The structures of the eight new compounds were elucidated on the basis of extensive NMR experiments and mass spectrometric measurements. The inhibitory activity of the compounds on the proteolytic cleavage of amyloid precursor protein by the aspartic protease BACE1 was evaluated. Both coumarano-chroma-4-ones and some isoflavones showed moderate activity in this assay.

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