PDF icon Download PDF
Semin Reprod Med 2012; 30(02): 084-091
DOI: 10.1055/s-0032-1307416
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Adverse Perinatal Events Associated with ART

Daniel Skora
1   The George Washington University, Medical Faculty Associates, Washington, District of Columbia
,
David Frankfurter
1   The George Washington University, Medical Faculty Associates, Washington, District of Columbia
› Author Affiliations
Further Information

Publication History

Publication Date:
27 April 2012 (online)

   Permissions and Reprints
Preview

Abstract

Since the advent of ART, much research has focused on the potential adverse for resultant harm. Prematurity, low birth-weight, PIH, congenital malformations, and CP are closely tied to multiple gestation. With the increase in elective single embryo transfer, there will be a reduction in adversity related to multiple birth. It is understood that underlying causes of infertility, including advanced maternal age, PCOS, thyroid disease, and uterine fibroids, predispose to adverse outcomes. However, imprinting abnormalities do not appear to stem from multiple births, and thus the need to consider the association between fertility treatment and methylation disorders remains essential. These, as well as risks of multi-fetal gestation, must be discussed with patients when considering using assisted reproduction.

Keywords

assisted reproduction - multiple birth - methylation disorder - perinatal morbidity and mortality - cerebral palsy - congenital malformation