Abstract
The effect of rutin (RT) on the expression of PPARγ in the skeletal muscle of db/db mice has been investigated. Thirty db/db mice were
randomized into 5 equal groups: model control group (MCG), positive control group
30 mg/kg pioglitazone hydrochloride (PCG), low-dose rutin group 50 mg/kg (LRT), middle-dose
rutin group 100 mg/kg (MRT), high-dose rutin group 200 mg/kg (HRT), and 6 other db/m
mice were used as the normal control (NC). The expression of PPARγ mRNA and protein in the skeletal muscle was determined by real-time quantitative
PCR and Western Blot, respectively. Treatment with HRT resulted in significant decreases
in the plasma levels of glucose and lipids (p < 0.001). Compared to the MCG, the expression
of PPARγ mRNA and protein of the skeletal muscle was significantly increased in the HRT and
PCG groups (p < 0.001 and p < 0.05, respectively). Rutin can increase the expression
of PPARγ in skeletal muscles of db/db mice.
Key words
rutin - PPAR
γ
- skeletal muscle - LPL
