Planta Med 2012; 78(5): 459-464
DOI: 10.1055/s-0031-1298156
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Spiranthenones A and B, Tetraprenylated Phloroglucinol Derivatives from the Leaves of Spiranthera odoratissima

Lorena Carneiro Albernaz1 , 2 , Alexandre Deville1 , Lionel Dubost1 , José Elias de Paula3 , Bernard Bodo1 , Philippe Grellier1 , Laila Salmen Espindola2 , Lengo Mambu1
  • 1UMR 7245 CNRS-MNHN Molécules de Communication et Adaptation des Micro-organismes, Muséum National d'Histoire Naturelle, Paris, France
  • 2Laboratório de Farmacognosia, Universidade de Brasília, Brasília, Brasil
  • 3Laboratório de Anatomia Vegetal, Instituto de Biologia, Universidade de Brasília, Brasília, Brasil
Further Information

Publication History

received October 12, 2011 revised Dec. 13, 2011

accepted Dec. 15, 2011

Publication Date:
23 January 2012 (online)

Abstract

Two new polyprenylated acylphloroglucinols, spiranthenones A (1) and B (2), a sesquiterpenoid, 6α-acetoxy,1β-hydroxyeudesm-4(15)-ene (3), along with sesamin and β-sitosterol, were isolated from the EtOAc extract of the leaves of Spiranthera odoratissima, and shown to display antiprotozoal activity. Their structures and relative stereochemistry were elucidated by NMR and mass spectrometry. These compounds exhibited moderate antiprotozoal activity, but without significant cytotoxicity against fibroblasts cell line NIH-3T3. Compound 3 was the most selective towards parasites.

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Dr. Lengo Mambu

UMR 7245 CNRS-MNHN
Molécules de Communication et Adaptation des Micro-organismes
Muséum National d'Histoire Naturelle

CP 54, 57 rue Cuvier

75231 Paris Cedex 05

France

Phone: +33 1 40 79 56 07

Fax: +33 1 40 79 31 35

Email: mambu@mnhn.fr

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