Agomelatine-Induced Akathisia with Concomitant Duloxetine Medication: A Case Report

Abstract

A 29-year-old depressed, otherwise healthy female patient was treated with agomelatine and duloxetine. She developed subsequent akathisia, which subsided after cessation of agomelatine. As a cause we suggest a pharmacodynamic drug-drug interaction leading to noradrenergic overstimulation. We recommend only gradual dose titration when combining the 2 substances to minimize the risk for side effects.

Key words

drug interaction - antidepressants - akathisia

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