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Pharmacopsychiatry 2012; 45(04): 162-163
DOI: 10.1055/s-0031-1297933
DOI: 10.1055/s-0031-1297933
Letter
Agomelatine-Induced Akathisia with Concomitant Duloxetine Medication: A Case Report
Authors
Further Information
Publication History
received 18 May 2011
revised 27 October 2011
accepted 08 November 2011
Publication Date:
30 January 2012 (online)
Abstract
A 29-year-old depressed, otherwise healthy female patient was treated with agomelatine and duloxetine. She developed subsequent akathisia, which subsided after cessation of agomelatine. As a cause we suggest a pharmacodynamic drug-drug interaction leading to noradrenergic overstimulation. We recommend only gradual dose titration when combining the 2 substances to minimize the risk for side effects.
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