Arzneimittelforschung 2010; 60(10): 587-592
DOI: 10.1055/s-0031-1296330
CNS-active Drugs · Hypnotics · Psychotropics · Sedatives
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and antidepressant-like action of 9-alkoxy-7H-furo[3,2-g]chromen-7-ones in mice

Xian-Qing Deng
1   College of Pharmacy, Yanbian University, Yanji, Jilin, P. R. China
,
Cheng-Xi Wei
1   College of Pharmacy, Yanbian University, Yanji, Jilin, P. R. China
2   Institute of Neurosurgery, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Autonomous Region, P. R. China
,
Ming-Xia Song
1   College of Pharmacy, Yanbian University, Yanji, Jilin, P. R. China
,
Zhe-Shan Quan
1   College of Pharmacy, Yanbian University, Yanji, Jilin, P. R. China
› Author Affiliations
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Publication History

Publication Date:
03 December 2011 (online)

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Abstract

The present study describes the chemical synthesis and pharmacological evaluation of a series of 9-alkoxy-7H-furo[3,2-g]-chromen-7-ones. The pharmacological results of these compounds show that nine of them, given orally, reduced the immobility time in the forced swimming test. The results of the open-field test further confirmed that these compounds possessed an antidepressant-like effect. In the 5-hydroxytryptophan induced head-twitch test, 9-(3-chlorobenzyloxy)-7H-furo[3,2-g]chromen-7-one (3m, 40 mg/kg p. o.) significantly increased the cumulative number of head twitches. This finding suggested that the antidepressant-like profile seems to involve the serotonergic system as underlying mechanism.