Dose-dependent pharmacokinetics of tyrosol galactoside as an anti-fatigue drug in rats

Abstract

Tyrosol galactoside (TG) is a new candidate anti-fatigue agent under development. In order to have a good understanding of its pharmacokinetic characters, the paper describes the dose-dependent pharmacokinetics of TG in rats after oral and intravenous administration. TG was rapidly absorbed after oral administration and cleared with first-order rate, for the plasma half-life was independent of dose. C_max and AUC_o–∞ after both intravenous and oral dosing were all linearly correlated with the dose, as the regression correlation coefficient (R) was 0.998, 0.989 and 0.994 for AUC_o–∞ (i. v., P < 0.01) AUCo–∞(i. g., P < 0.01) and C_max (i. g., P < 0.01), respectively. However, these parameters increased less than proportionally with increasing dose. In addition, the apparent volume of distribution (Vd) and the apparent clearance (Cl) seemed to be affected by the dose.

Key words

Anti-fatigue candidate drug - Dose-dependent pharmacokinetics - Tyrosol galactoside

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