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Arzneimittelforschung 2011; 61(8): 435-438
DOI: 10.1055/s-0031-1296224
CNS-active Drugs · Hypnotics · Psychotropics · Sedatives
Editio Cantor Verlag Aulendorf (Germany)

Dose-dependent pharmacokinetics of tyrosol galactoside as an anti-fatigue drug in rats

Deng Yating
1   Department of Pharmacology, Fourth Military Medical University, Xi’an, PR China
,
Wang Qingwei
2   Department of Pharmacy, The Second Affiliated Hospital, Fourth Military Medical University, Xi’an, PR China
,
Liu Xueying
3   Department of Medicinal Chemistry, Fourth Military Medical University, Xi’an, PR China
,
Wang Yu
3   Department of Medicinal Chemistry, Fourth Military Medical University, Xi’an, PR China
,
Ding Zijie
3   Department of Medicinal Chemistry, Fourth Military Medical University, Xi’an, PR China
› Author Affiliations
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Publication History

Publication Date:
27 November 2011 (online)

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Abstract

Tyrosol galactoside (TG) is a new candidate anti-fatigue agent under development. In order to have a good understanding of its pharmacokinetic characters, the paper describes the dose-dependent pharmacokinetics of TG in rats after oral and intravenous administration. TG was rapidly absorbed after oral administration and cleared with first-order rate, for the plasma half-life was independent of dose. Cmax and AUCo–∞ after both intravenous and oral dosing were all linearly correlated with the dose, as the regression correlation coefficient (R) was 0.998, 0.989 and 0.994 for AUCo–∞ (i. v., P < 0.01) AUCo–∞(i. g., P < 0.01) and Cmax (i. g., P < 0.01), respectively. However, these parameters increased less than proportionally with increasing dose. In addition, the apparent volume of distribution (Vd) and the apparent clearance (Cl) seemed to be affected by the dose.

Key words

Anti-fatigue candidate drug - Dose-dependent pharmacokinetics - Tyrosol galactoside
 

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