Arzneimittelforschung 2011; 61(3): 148-152
DOI: 10.1055/s-0031-1296181
Cardiac Drugs · Cardiac Stimulants · Coronary Drugs
Editio Cantor Verlag Aulendorf (Germany)

Effect of 20 (S)-protopanaxatriol and its epimeric derivatives on myocardial injury induced by isoproterenol

Bing Han
1   Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, P. R. China
,
Qingguo Meng
1   Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, P. R. China
,
Qiang Li
2   Department of Pathology, Yantaishan Hospital, Yantai, P. R. China
,
Jiangfeng Zhang
1   Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, P. R. China
,
Yi Bi
1   Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, P. R. China
,
Naicai Jiang
1   Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, P. R. China
› Author Affiliations
Further Information

Publication History

Publication Date:
28 November 2011 (online)

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Abstract

Objective: It was reported Panax ginseng had diverse components and multifaceted pharmacological functions. This study aims to investigate the effect of 20 (S)-protopanaxatriol (PT, CAS 179799-20-3) and its epimeric derivatives (20S, 24R-epoxy-dammarane-3β, 6α, 12β, 25-tetraol, PTD1 and 20S, 24S-epoxy-dammarane-3β, 6α, 12β, 25-tetraol, PTD2) on myocardial injury induced by isoproterenol in rats.

Methods: Male Wistar rats were administered orally 20 (S)-protopanaxatriol or its epimeric derivatives for 7 days. Four days after treatment, all rats, except those in the control group, were subcutaneously injected with isoproterenol (20 mg/kg) for 3 consecutive days. Two hours after the last isoproterenol injection, the rats were anaesthetized and sacrificed. The biochemical parameters were assayed and pathological examination of the heart tissues was performed.

Results: Administration of PT and PTD1 resulted in a reduction in creatine kinase and lactate dehydrogenase. PT and PTD1 inhibited not only the elevation of malondialdehyde content, but also the reduction of superoxide dismutase activity, glutathione peroxidase and total antioxidant capacity. The pathohistological changes induced by isoproterenol were also ameliorated by PT and PTD1.

Conclusion: The present findings suggest that PT and PTD1 exerted cardioprotective effects against myocardial ischemic injury by enhancing the anti-free-radical actions of heart tissues. Furthermore the results indicated that the configuration of C-24 of the funan ring was involved in the pharmacological action of the epimeric derivatives of 20(S)-protopanaxatriol.