Endoscopy 2012; 44(S 02): E167-E168
DOI: 10.1055/s-0031-1291758
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

First report of a mucosa-associated lymphoid tissue (MALT) lymphoma of the esophagus diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)


T. Ogura1, 2, M. Tajika3, S. Hijioka1, K. Hara1, S. Haba1, W. Hosoda4, Y. Yatabe4, S. Asano5, K. Higuchi2, K. Yamao1, Y. Niwa3
  • 1Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
  • 22nd Department of Internal Medicine, Osaka Medical College, Osaka, Japan
  • 3Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan
  • 4Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
  • 5Department of Respiratory Medicine, Handa Municipal Hospital, Nagoya, Japan
Further Information

Corresponding author

M. Tajika
1-1 Kanokoden
Chikusa-ku
Nagoya 464-8681
Japan   
Fax: +81-527635233   

Publication History

Publication Date:
23 May 2012 (online)

 

Mucosa-associated lymphoid tissue (MALT) lymphoma of the esophagus is a rare tumor [1] [2] [3] with varying presentations [4]. Only a few reports have described MALT lymphoma of the esophagus spanning the entire circumference and length of the esophagus [3]. Many of these cases were diagnosed surgically. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is an established method of obtaining submucosal tissue specimens [5]. We report here the first case of MALT lymphoma of the esophagus diagnosed by EUS-FNA.

A 60-year-old woman attended our institution due to dysphagia. Upper gastrointestinal endoscopy revealed a smooth surface with visible capillaries over the entire circumference of the esophagus and a white, soft, elastic submucosal tumor covered by normal mucosa ([Fig. 1]). An esophagogram showed a slightly elevated submucosal tumor extending over the entire esophageal length ([Fig. 2]), and enhanced computed tomography demonstrated thickening of the left bronchial and esophageal walls along with swelling of the pharyngeal lymph nodes. Endoscopic ultrasonography revealed a tumorous lesion presenting as a primarily hypoechoic mass arising in the third layer, with a hyperechoic region.

Zoom Image
Fig. 1 Endoscopic findings in a 60-year-old woman with dysphagia: a large, rounded mass with normal overlying mucosa is seen extending longitudinally along the entire esophagus.
Zoom Image
Fig. 2 Esophagogram showing a large submucosal tumor with luminal narrowing of the whole of the esophagus.

Because a diagnosis was not reached using specimens obtained with biopsy forceps, EUS-FNA was performed ([Fig. 3]). The presence of small- to medium-sized lymphocytic cells with mildly irregular nuclei, along with CD5(–), CD10(–), CD19(+), CD20(+), CD22 (+), and λ monoclonality on flow cytometry, led to a diagnosis of MALT lymphoma of the esophagus ([Fig. 4]). We described the tumor as a malignant, extramarginal zone B-cell lymphoma of the MALT type, clinical stage IV (Lugano International Conference classification). The patient was treated with a total of six courses of chemotherapy with rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone (R-CHOP), and a complete response was achieved.

Zoom Image
Fig. 3 Endoscopic ultrasound showing a hypoechoic thickening in the third layer. Endoscopic ultrasound-guided fine-needle aspiration was carried out using a 22-G needle (arrows).
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Fig. 4 Small- to medium-sized lymphocytic cells with mildly irregular nuclei.

To the best of our knowledge, this is the first report of EUS-FNA diagnosis of MALT lymphoma of the esophagus.

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Competing interests: None

Corresponding author

M. Tajika
1-1 Kanokoden
Chikusa-ku
Nagoya 464-8681
Japan   
Fax: +81-527635233   
Zoom Image
Fig. 1 Endoscopic findings in a 60-year-old woman with dysphagia: a large, rounded mass with normal overlying mucosa is seen extending longitudinally along the entire esophagus.
Zoom Image
Fig. 2 Esophagogram showing a large submucosal tumor with luminal narrowing of the whole of the esophagus.
Zoom Image
Fig. 3 Endoscopic ultrasound showing a hypoechoic thickening in the third layer. Endoscopic ultrasound-guided fine-needle aspiration was carried out using a 22-G needle (arrows).
Zoom Image
Fig. 4 Small- to medium-sized lymphocytic cells with mildly irregular nuclei.