The Serotonin Transporter Promoter Polymorphism (5-HTTLPR) Affects the Relation between Antidepressant Serum Concentrations and Effectiveness in Major Depression

N. Dreimüller; A. Tadić; A. Dragicevic; K. Boland; B. Bondy; K. Lieb; G. Laux; W. Maier; M. J. Müller; M. L. Rao; M. Rietschel; J. Röschke; P. Zill; C. Hiemke

doi:10.1055/s-0031-1291347

Pharmacopsychiatry, Inhaltsverzeichnis

Pharmacopsychiatry 2012; 45(03): 108-113
DOI: 10.1055/s-0031-1291347

Original Paper

The Serotonin Transporter Promoter Polymorphism (5-HTTLPR) Affects the Relation between Antidepressant Serum Concentrations and Effectiveness in Major Depression

N. Dreimüller

¹Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany

,

A. Tadić

¹Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany

,

A. Dragicevic

¹Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany

,

K. Boland

²Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

,

B. Bondy

³Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany

,

K. Lieb

¹Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany

,

G. Laux

⁴Inn-Salzach Hospital, Wasserburg a. Inn, Germany

,

W. Maier

²Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

,

M. J. Müller

⁵Clinic for Psychiatry and Psychiatry Marburg-Süd, Marburg, Germany

,

M. L. Rao

²Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

,

M. Rietschel

⁶Central Institute of Mental Health, Division of Genetic Epidemiology in Psychiatry, Mannheim, Germany

,

J. Röschke

⁷SCIVIAS St. Valentinus-Hospital, Kiedrich/Rheingau, Germany

,

P. Zill

³Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany

,

C. Hiemke

¹Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany

› Institutsangaben

Abstract

Introduction:

Both the serotonin transporter promotor polymorphism (5-HTTLPR) and serum concentrations of SSRIs have been shown to affect response to SSRIs. Results, however, are inconsistent. The aim of this study was to investigate whether remission or response to SSRIs is influenced by an interaction of 5-HTTLPR and SSRI serum concentrations.

Methods:

49 patients with major depression and SSRI treatment were genotyped for the 5-HTTLPR locus including the rs25531. Drug serum concentrations and depression severity were measured weekly.

Results:

Logistic regression analysis revealed a significant association between 5-HTTLPR, SSRI serum concentrations and response to treatment. A favourable treatment outcome correlated with SSRI serum concentration in 5-HTTLPR-L_A allele carriers (r²=34.3%; p=0.001), but not in S/L_G-allele carriers (p=0.31)

Discussion:

In the group of L_A allele carriers, those MDD patients with a high antidepressant serum concentrations responded better to treatment than patients with a low serum concentration. We conclude that the 5-HTTLPR might affect reponse to SRRI subject to serum concentrations. If replicated this might be a starting point for prospective clinical trials.

Key words

5-HTTLPR - SSRI - TDM - depression

Volltext

Referenzen

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