Pharmacopsychiatry 2012; 45(02): 77-79
DOI: 10.1055/s-0031-1291234
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Report of a Case of Steroid-Induced Psychosis and Inappropriate Sexual Behaviour in an Adolescent

T. Demir
1   Department of Child and Adolescent Psychiatry, University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey
,
G. Karacetin
1   Department of Child and Adolescent Psychiatry, University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey
,
B. Dogangun
1   Department of Child and Adolescent Psychiatry, University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey
,
N. Kocabasoglu
2   Department of Psychiatry, University of Istanbul, Cerrahpasa Medical Faculty, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

received 24 April 2011
revised 12 August 2011

accepted 19 September 2011

Publication Date:
15 November 2011 (online)

Abstract

We present the case of an acute steroid-induced psychosis in a 17-year-old boy who presented with inappropriate sexual behaviour. Quetiapine treatment was initiated at an initial dosage of 300 mg/day. The dosage was increased to 900 mg/day on the fourth day of the treatment. The patient’s symptoms began to improve in the second week and were resolved by the fourth week of quetiapine treatment. Steroid use may result in a psychosis, including inappropriate sexual behaviour. Clinicians should be very cautious while administering these drugs and should consider and monitor side effects carefully.

 
  • References

  • 1 Kershner P, Wang-Cheng R. Psychiatric side effects of steroid therapy. Psychosomatics 1989; 30: 135-139
  • 2 Sirois F. Steroid psychosis: a review. Gen Hosp Psychiatry 2003; 25: 27-33
  • 3 Kramer TM, Cottingham EM. Risperidone in the treatment of steroid-induced psychosis. J Child Adolesc Psychopharmacol 1999; 9: 315-316
  • 4 Beshay H, Pumariega AJ. Sertraline treatment of mood disorder associated with prednisone: a case report. J Child Adolesc Psychopharmacol 1998; 8: 187-193
  • 5 Connett G, Lenny W. Inhaled budesonide and behavioural disturbances. Lancet 1991; 338: 634-635
  • 6 El-Gabalawi F, Johnson R. Hypersexuality in inpatient children and adolescents: recognition, differential diagnosis, and evaluation. CNS Spectr 2007; 12: 821-827
  • 7 Trenton AJ, Currier GW. Behavioural manifestations of anabolic steroid use. CNS Drugs 2005; 19: 571-595
  • 8 Janicki S, Franco K, Zarko R. A case report of Kleine-Levin syndrome in an adolescent girl. Psychosomatics 2001; 42: 350-352
  • 9 Coskun M, Zoroglu S. A report of two cases of sexual side effects with OROS methylphenidate. J Child Adolesc Psychopharmacol 2009; 19: 477-479
  • 10 Grabowska-Grzyb A, Nagańska E, Wolańczyk T. Hypersexuality in two patients with epilepsy treated with lamotrigine. Epilepsy Behav 2006; 8: 663-665
  • 11 Elmore JL, Quattlebaum JT. Female sexual stimulation during antidepressant treatment. Pharmacotherapy 1997; 17: 612-616
  • 12 Chollet CA, Andreatini R. Effect of bupropion on sexual dysfunction induced by fluoxetine: a case report of hypersexuality. J Clin Psychiatry 2003; 64: 1268-1269
  • 13 Lai CH. Duloxetine related hypersexuality: a case report. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 414-415
  • 14 Cannas A, Solla P, Floris G et al. Hypersexual behaviour, frotteurism and delusional jealousy in a young parkinsonian patient during dopaminergic therapy with pergolide: A rare case of iatrogenic paraphilia. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 1539-1541
  • 15 Malhotra S, Das MK, Gupta N et al. A clinical study of Kleine-Levin syndrome with evidence for hypothalamic-pituitary axis dysfunction. Biol Psychiatry 1997; 42: 299-301
  • 16 Cohen MJ, Park YD, Kim H et al. Long-term neuropsychological follow-up of a child with Klüver-Bucy syndrome. Epilepsy Behav 2010; 19: 643-646