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Synfacts 2011(11): 1261-1261  
DOI: 10.1055/s-0031-1289223
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Transfer Hydrogenation with Immobilized Wilkinson’s Catalyst

Contributor(s): Yasuhiro Uozumi, Aya Tazawa
K. Bogár*, P. Krumlinde, Z. Bacsik, N. Hedin, J.-E. Bäckvall*
Stockholm University and AstraZeneca R&D, Södertälje, Sweden
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

Silica gel supported Wilkinson’s catalyst 1 was prepared by functionalization of activated silica gel with 3-(diphenylphosphanyl)propyltriethylsilane followed by treatment with RhCl(PPh3)3 (eq. 1). The immobilized catalyst 1 promoted the transfer hydrogenation of carbonyl compounds in the presence of Na2CO3 to afford the corresponding alcohols in up to >99% yield (20 examples, eq. 2).