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Synfacts 2011(11): 1194-1194  
DOI: 10.1055/s-0031-1289222
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ni-Catalyzed Reductive Cycloaddition

Contributor(s): Mark Lautens, Lei Zhang
A. D. Jenkins, A. Herath, M. Song, J. Montgomery*
University of Michigan, Ann Arbor, USA
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

Simple even-numbered π-systems, such as alkenes and alkynes, are attractive coupling partners in the formation of five-membered rings. Following up on their original work (J. Am. Chem. Soc. 2006, 128, 14030), the authors report an expanded scope and gain access to cyclopentenones using the reductive cycloaddition strategy.