Synfacts 2011(11): 1206-1206  
DOI: 10.1055/s-0031-1289214
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Asymmetric Allylations

Contributor(s): Mark Lautens, Hasnain A. Malik
A. Hassan, I. A. Townsend, M. J. Krische*
University of Texas at Austin, USA
Further Information

Publication History

Publication Date:
19 October 2011 (online)

Significance

The Grignard Nozaki-Hiyama allyl­ation of aldehydes is one of the most straightforward means to construct homoallylic alcohols. There has been a concerted effort by the synthetic community to provide asymmetric variants of this transformation. The Krische group has demonstrated that transfer hydrogenation is a versatile means to apply alcohols (as precursors to aldehydes) and π-unsaturated reactants in enantio­selective allylations. It is remarkable that electrophiles in the alcohol oxidation state can be utilized without the necessity of stoichiometric metal reductants.