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Synfacts 2011(11): 1199-1199  
DOI: 10.1055/s-0031-1289213
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Asymmetric 1,3-Dipolar Cycloadditions

Contributor(s): Mark Lautens, Hasnain A. Malik
T.-L. Liu, Z.-L. Hea, C.-J. Wang*
Wuhan University, P. R. of China
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Publication History

Publication Date:
19 October 2011 (online)

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Significance

Chromanones are a class of highly bioactive natural products receiving much synthetic interest. Pyrrolidines are known to be present in an array of pharmaceuticals and natural alkaloids. The ability to arrive at these structural motifs in an asymmetric fashion from readily accessible achiral reagents is noteworthy.