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Synfacts 2011(11): 1211-1211  
DOI: 10.1055/s-0031-1289211
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Domino Knovenagel/Pinner/Friedel-Crafts Synthesis of Chiral Chromenes

Contributor(s): Mark Lautens, Stephen G. Newman
W. Chen, Y. Cai, X. Fu, X. Liu, L. Lin, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication Date:
19 October 2011 (online)

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Significance

Optically active 2-amino-4H-chro­menes can be found in a number of interesting, ­biologically active molecules. By combining sali­cylaldehydes, malononitrile, and indoles with a chiral Lewis acid catalyst, the authors can prepare members of this family in a highly efficient asymmetric reaction.