Base-Mediated Transition-Metal-Free Alkynylation of Aryl Chlorides

Significance

Herein, two strategies for a transition-metal-free alkynylation of aryl chlorides are disclosed. The first set involves the use of TMPLi as base in pentane-THF, THF or diethyl ether at ambient temperature, while the second method uses metal alkoxides, such as t-BuONa and t-BuOK, in dioxane at temperatures up to 135 ˚C.