Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Download PDF
Synfacts 2011(11): 1230-1230
DOI: 10.1055/s-0031-1289201
DOI: 10.1055/s-0031-1289201
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New Yorkγ-Selective Cross-Coupling of Allylic Silanolate Salts
S. E. Denmark*, N. S. Werner
University of Illinois at Urbana-Champaign, USA
Further Information
Publication History
Publication Date:
19 October 2011 (online)
Significance
In this work, a γ-selective, palladium-catalyzed cross-coupling of sodium (Z)-2-butenyldiethylsilanolate is disclosed. The silanolate salt is easily prepared and configurationally stable. High yields are obtained for electron-poor, -rich, sterically demanding, and heteroaromatic bromides.