Synfacts 2011(11): 1208-1208  
DOI: 10.1055/s-0031-1289191
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

3-Aminochroman Derivatives via Ruthenium-Catalyzed Asymmetric Hydrogenation

Contributor(s): Hisashi Yamamoto, Dmitry L. Usanov
Z. Wu, T. Ayad*, V. Ratovelomanana-Vidal*
Chimie ParisTech, France
Further Information

Publication History

Publication Date:
19 October 2011 (online)

Significance

The 3-aminochroman moiety can be found in a number of pharmaceutically important compounds; however, limited progress in development of the enantioselective synthetic approaches to its construction has been achieved. This work describes the highly enantioselective Ru-mediated hydrogenation leading to 3-amino­chroman derivatives with 60-97% yield and 34-96% ee.