RSS-Feed abonnieren
DOI: 10.1055/s-0031-1281597
© Georg Thieme Verlag KG Stuttgart · New York
Perinatale Zwangsstörungen
Perinatal Obsessive-Compulsive DisorderPublikationsverlauf
Publikationsdatum:
09. August 2011 (online)

Zusammenfassung
Unter einer perinatalen Zwangsstörung versteht man die Erstmanifestation bzw. Exazerbation von Zwangssymptomen während einer Schwangerschaft und/oder post partum. Über die Häufigkeit von Zwangsstörungen in der allgemein für psychische Erkrankungen als vulnerabel geltenden perinatalen Phase gibt es kaum verlässliche Daten. Klinisch überwiegen bei der eher multifaktoriell bedingten perinatalen Zwangsstörung Zwangsgedanken und Zwangshandlungen, die im Zusammenhang mit der Sorge um das Wohl des Ungeborenen bzw. Neugeborenen stehen. Eine differenzialdiagnostische Abgrenzung gegenüber Schwangerschaftspsychosen und postpartalen Depressionen ist oft schwierig. Bei der Behandlung sollten nicht medikamentöse Strategien bevorzugt werden und der Einsatz der SSRIs sollte streng indiziert erfolgen. Insgesamt jedoch liegen zu perinatalen Zwangsstörungen kaum kontrollierte Untersuchungen vor und das Wissen über diese spezielle Patientengruppe ist eher als gering einzustufen. Ziel dieser Übersichtsarbeit ist es, die perinatale Zwangsstörung hinsichtlich Phänomenologie, Pathogenese, Differenzialdiagnostik und Therapiemaßnahmen näher darzustellen. Ein frühzeitiges Erkennen und Einleiten von Therapiemaßnahmen erscheint von großer Bedeutung für den Aufbau einer guten und längerfristig stabilen Mutter-Kind-Beziehung zu sein.
Abstract
A perinatal obsessive-compulsive disorder (OCD) is defined as an illness exhibiting first symptoms in the context of pregnancy and the postpartal period. There are no valid data up to date concerning the incidence of OCD, which might be of multifactorial origin, in this period in which females are highly vulnerable for psychiatric diseases. From a clinical point of view, obsessions and compulsions are mainly related to the well-being of the foetus or newborn baby. Differential diagnosis of perinatal OCD including pregnancy psychosis and post-partum depression is often difficult. Concerning treatment, non-pharmacological approaches should be preferred. Administration of SSRIs should be strongly restricted. However, there are no controlled therapy studies in patients with perinatal OCD. Furthermore, current knowledge about these patients is still limited. The aim of this review article is the presentation of phenomenology, pathogenesis, differential diagnosis and treatment of perinatal OCD. The mental situation of the female patients can be improved and stabilised if early diagnosis of a perinatal OCD leads to early initiation of an adequate therapy. This will then enable a good and stable mother-child relationship to develop.
Schlüsselwörter
Zwangsstörung - Schwangerschaft - Postpartum
Keywords
obsessive-compulsive disorder - pregnancy - postpartum period
Literatur
- 1 Zaudig M. Epidemiologie, Komorbidität und Verlauf der Zwangsstörung. In: Zaudig M, Hauke W, Hegerl U, Hrsg Die Zwangsstörung, Diagnostik und Therapie. 2. Aufl. Stuttgart: Schattauer; 2002: 33-39
MissingFormLabel
- 2
Ross L E, McLean L M.
Anxiety disorders during pregnancy and the postpartum period: a systematik review.
J Clin Psychiatry.
2006;
67
1285-1298
MissingFormLabel
- 3
Neziroglu F, Anemone R, Yaryura-Tobias J A.
Onset of obsessive-compulsive disorder in pregnancy.
Am J Psychiatry.
1992;
149
947-950
MissingFormLabel
- 4
Williams K E, Koran L M.
Obsessive-compulsive disorder in pregnancy, the puerperium, and the premenstruum.
J Clin Psychiatry.
1997;
58
330-334
MissingFormLabel
- 5
Abramowitz J S, Schwartz S A, Moore K M et al.
Obsessive-compulsive symptoms in pregnancy and the puerperium: a review of the literature.
J Anxiety Disorders.
2003;
17
461-478
MissingFormLabel
- 6
Kalra H, Tandon R, Trivedi J K et al.
Pregnancy-induced obsessive compulsive disorder: a case report.
Annals of Generaly Psychiatry.
2005;
4
1-3
MissingFormLabel
- 7
Uguz F, Gezginc K, Zeytinci I E et al.
Obsessive-compulsive disorder in pregnant women during the third trimester of pregnancy.
Comprehensive Psychiatry.
2007;
48
441-445
MissingFormLabel
- 8
Uguz F, Gezginc K, Kayhan F et al.
Is pregnancy associated with mood and anxiety disorders? A cross-sectional study.
Gen Hosp Psychiatry.
2010;
32
213-215
MissingFormLabel
- 9
Forray A, Fosseneanu M, Pittman B et al.
Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum
period.
J Clin Psychiatry.
2010;
71
1061-1068
MissingFormLabel
- 10
Sichel D A, Cohen L S, Dimmock J A et al.
Postpartum obsessive compulsive disorder: a case series.
J Clin Psychiatry.
1993;
54
156-159
MissingFormLabel
- 11
Arnold L M.
A case series of women with postpartum-onset obsessive-compulsive disorder.
Prim Care Companion J Clin Psychiatry.
1999;
1
103-108
MissingFormLabel
- 12
Labad J, Menchon J M, Alonso P et al.
Female reproductive cycle and obsessive-compulsive disorder.
J Clin Psycchiatry.
2005;
66
428-435
MissingFormLabel
- 13
Zambaldi C F, Cantilino A, Montenegro A C et al.
Postpartum obsessive-compulsive disorder:prevalence and clinical characteristics.
Comprehensive Psychiatry.
2009;
50
503-509
MissingFormLabel
- 14 Niedermeier N, Zaudig M. Definition und Beschreibung der Zwangsphänomene. In: Zaudig M, Hauke W, Hegerl U, Hrsg Die Zwangsstörung, Diagnostik und Therapie. 2. Aufl. Stuttgart: Schattauer; 2002: 1-11
MissingFormLabel
- 15
Brockington I F, Macdonald E, Wainscott G.
Anxiety, obsessions and morbid preoccupations in pregnancy and the puerperium.
Arch Womens Ment Health.
2006;
9
253-263
MissingFormLabel
- 16
Martini J, Wittchen H U, Soares C N et al.
New women-specific diagnostic modules: the Composition International Diagnostic Interview
for Women (CIDI-VENUS).
Arch Womens Ment Health.
2009;
12
281-289
MissingFormLabel
- 17
Austin M P.
Classification of mental health disorders in the perinatal period: future directions
for DSM-V and ICD-11.
Arch Womens Ment Health.
2010;
13
41-44
MissingFormLabel
- 18 Mavrogiorgou P, Juckel G. Depressive Störungen im Rahmen des weiblichen Zyklus und der Schwangerschaft. In: Hegerl U, Hoff P, Hrsg. Depressionsbehandlung unter komplizierenden Bedingungen.. Bremen: Uni-Med; 2003: 76-88
MissingFormLabel
- 19
Leung B M, Kaplan B J.
Perinatal depression: prevalence, risks, and the nutrition link - a review of the
literature.
J Am Diet Assoc.
2009;
109
1566-1575
MissingFormLabel
- 20
Lancaster C A, Gold K J, Flynn H A et al.
Risk factors for depressive symptoms during pregnancy: a systematic review.
Am J Obstet Gynecol.
2010;
202
5-14
MissingFormLabel
- 21
Riecher-Rössler A.
Psychische Störungen und Erkrankungen nach der Entbindung.
Fortschr Neurol Psychiat.
1997;
65
97-107
MissingFormLabel
- 22
Watkins M E, Newport D J.
Psychosis in pregnancy.
Obstet Gynecol.
2009;
113
1349-1353
MissingFormLabel
- 23
Van Mullen C, Tillet J.
Psychiatric disorders in pregnancy.
J Perinatal Neonatal Nurs.
2009;
23
124-130
MissingFormLabel
- 24
Kendell R E, Chalmers J C, Platz C.
Epidemiology of puerperal psychoses.
Brit J Psychiat.
1987;
150
662-673
MissingFormLabel
- 25
Jones I, Heron J, Blackmore E R et al.
Incidence of hospitalization for postpartum psychotic and bipolar episodes.
Arch Gen Psychiatry.
2008;
65
356
MissingFormLabel
- 26
Spinelli M G.
Postpartum psychosis: detection of risk and management.
Am J Psychiatry.
2009;
166
405-408
MissingFormLabel
- 27
Sharma V, Khan M.
Identification of bipolar disorder in women with postpartum depression.
Bipolar Disord.
2010;
12
335-340
MissingFormLabel
- 28
Doucet S, Dennis C L, Letourneau N et al.
Differentiation and clinical implications of postpartum depression and postpartum
psychosis.
J Obstet Gynecol Neonatal Nurs.
2009;
38
269-279
MissingFormLabel
- 29
Bergink V, Koorengevel K M.
Postpartum depression with psychotic features.
Am J Psychiatry.
2010;
167
476-477
MissingFormLabel
- 30
Wisner K, Moses-Kolko E L, Sit D KY.
Postpartum depression: a disorder in search of a definition.
Arch Womens Ment Health.
2010;
13
37-40
MissingFormLabel
- 31
Abramowitz J S, Meltzer-Brody S, Leserman J et al.
Obsessional thoughts and compulsive behaviors in a sample of women with postpartum
mood symptoms.
Arch Womens Ment Health.
2010;
DOI: 10.1007 /s00737-010-0172-4
MissingFormLabel
- 32
Friedman S H, Resnick P J.
Postpartum depression: an update.
Womens Health.
2009;
5
287-295
MissingFormLabel
- 33
Sichel D A, Cohen L S, Rosenbaum J F et al.
Postpartum onset of obsessive-compulsive disorder.
Psychosomatics.
1993;
34
277-279
MissingFormLabel
- 34
Wisner K L, Peindl K S, Gigliotti T et al.
Obsessions and compulsions in women with postpartum depression.
J Clin Psychiatry.
1999;
60
176-180
MissingFormLabel
- 35
Wenzel A, Haugen E N, Jackson L C et al.
Anxiety symptoms and disorders at eight weeks postpartum.
J Anxiety Disord.
2005;
19
295-311
MissingFormLabel
- 36
Navarro P, Garcia-Esteve L, Ascaso C et al.
Non-psychotic psychiatric disorders after childbirth: prevalence and comorbidity in
a community sample.
J Affect Disord.
2008;
109
171-176
MissingFormLabel
- 37
Voderholzer U.
Obsessive-compulsive disorders.
Fortschr Neurol Psychiatr.
2005;
73
526-542
MissingFormLabel
- 38
Zurowski B, Hohagen F, Kordon A.
Neurobiologie der Zwangsstörung. Teil 1: Konzepte zur Pathophysiologie und Genetik.
Nervenheilkunde.
2009;
9
625-630
MissingFormLabel
- 39
Zurowski B, Hohagen F, Kordon A.
Neurobiologie der Zwangsstörung. Teil 2: Konzepte und Befunde aus der Neurobildgebung.
Nervenheilkunde.
2009;
11
809-816
MissingFormLabel
- 40
Lasiuk G C, Hegadoren K M.
The effects of estradiol on central serotonergic systems and its relationship to mood
in women.
Biol Res Nurs.
2007;
9
147-160
MissingFormLabel
- 41
Rybaczyk L A, Bashaw M J, Pathak D R et al.
An overlooked connection: serotonergic mediation of estrogen-related physiology and
pathology.
BMC Womens Health.
2005;
20
5-12
MissingFormLabel
- 42
Amin Z, Canli T, Epperson C N.
Effect of estrogen-serotonin interactions on mood and cognition.
Behav Cogn Neurosci Rev.
2005;
4
43-58
MissingFormLabel
- 43
Ladisich W.
Influence of progesterone on serotonin metabolism: a possible causal factor for mood
changes.
Psychoneuroendokrinology.
1977;
2
257-266
MissingFormLabel
- 44
Le Melledo J M, Baker G.
Role of progesterone and other neuroactive steroids in anxiety disorders.
Expert Rev Neurother.
2004;
4
851-860
MissingFormLabel
- 45
Den Boer J A, Westenberg H G.
Oxytocin in obsessive-compulsive disorder.
Peptides.
1992;
13
1083-1085
MissingFormLabel
- 46
Leckman J F, Goodman W K, North W G et al.
Elevated cerebrospinal fluid levels of oxytocin in obsessive-compulsive disorder.
Comparison with Tourette`s syndrome and healthy controls.
Arch Gen Psychiatry.
1994;
51
82-92
MissingFormLabel
- 47
Marazziti D, Catena Dellòsso M.
The role of oxytocin in neuropsychiatric disorders.
Curr Med Chem.
2008;
15
698-704
MissingFormLabel
- 48
Altemus M, Jacobson K R, Debellis M et al.
Normal CSF oxytocin and NPY levels in OCD.
Biol Psychiatry.
1999;
45
931-933
MissingFormLabel
- 49
Epperson C N, McDougle C J, Price L H.
Intranasal oxytocin in obsessive-compulsive disorder.
Biol Psychiatry.
1996;
40
547-549
MissingFormLabel
- 50
Altemus M, Pigott T, Kalogeras K T et al.
Abnormalities in the regulation of vasopressin and corticotropin releasing factor
secretion in obsessive-compulsive disorder.
Arch Gen Psychiatry.
1992;
49
9-20
MissingFormLabel
- 51
Kluge M, Schüssler P, Künzel H E et al.
Increased nocturnal secretion of ACTH and cortisol in obsessive-compulsive disorder.
J Psychiatry Res.
2007;
41
928-933
MissingFormLabel
- 52
Gustafsson P E, Gustafsson P A, Ivarsson T et al.
Diurnal cortisol levels and cortisolresponse in youths with obsessive-compulsive disorder.
Neuropsychobiology.
2007;
57
14-21
MissingFormLabel
- 53
Brunton P J, Russel J A.
The expectant brain: adapting for motherhood.
Nature Rev Neuroscience.
2008;
9
11-25
MissingFormLabel
- 54
Vasconcelos M S, Sampaio A S, Hounie A G et al.
Prenatal, Perinatal, and postnatal risk factors in obsessive-compulsive disorder.
Biol Psychiatry.
2007;
61
301-307
MissingFormLabel
- 55
Leckman J F, Mayes L C, Feldman R et al.
Early parental preoccupations and behaviors and their possible relationship to the
symptoms of obsessive-compulsive disorder.
Acta Psychiatr Scand Suppl.
1999;
398
1-26
MissingFormLabel
- 56
Fairbrother N, Abramowitz J S.
New parenthood as a risk factor for the development of obsessional problems.
Beh Res Ther.
2007;
45
2155-2163
MissingFormLabel
- 57
Mowrer O H.
On the dual nature of learning-a re-interpretation of „conditioning and „problem solving”.
Harvard Educational Review.
1947;
17
102-148
MissingFormLabel
- 58 Niedemeier N, Bossert-Zaudig S. Psychologische Modelle zur Erklärung der Entstehung und Aufrechterhaltung von Zwangsstörungen. In: Zaudig M, Hauke W, Hegerl U, Hrsg. Die Zwangsstörung, Diagnostik und Therapie. 2. Aufl. Stuttgart: Schattauer; 2002: 65-72
MissingFormLabel
- 59
Salkovskis P, Forrester E, Richards C.
Cognitive-behavioral approach to understanding obsessional thinking.
Br J Psychiatry.
1998;
35
53-63
MissingFormLabel
- 60
Varkukla M, Viguera A C, Gonsalves L.
Depression and pregnancy.
Compr Ther.
2009;
35
44-49
MissingFormLabel
- 61 Hegerl U, Mavrogiorgou P. Biologische Grundlagen von Zwangsstörungen. In: Zaudig M, Hauke W, Hegerl U, Hrsg Die Zwangsstörung, Diagnostik und Therapie. 2. Aufl Stuttgart: Schattauer; 2002: 43-63
MissingFormLabel
- 62
Brüne M.
The evolutionary psychology of obsessive-compulsive disorder. The role of cognitive
metarepresentation.
Perspectives in Biology and Medicine.
2006;
49
317-329
MissingFormLabel
- 63
Mataix-Cols D, do Rosario-Campos M C, Leckman J F.
A multidimensional model of obsessive-compulsive disorder.
Am J Psychiatry.
2005;
162
228-238
MissingFormLabel
- 64
Leckman J F.
An evolutionary and developmental perspective.
Biol Psychiatry.
2007;
62
831-832
MissingFormLabel
- 65
Saad G.
sex differences in OCD symptomatology: an evolutionary perspective.
Medical Hypotheses.
2006;
67
1455-1459
MissingFormLabel
- 66
Brandes M, Soares C N, Cohen L S.
Postpartum onset obsessive-compulsive disorder: diagnosis and management.
Arch Womens Ment Health.
2004;
7
99-110
MissingFormLabel
- 67
Misri S, Milis L.
Obsessive-compulsive disorder in the postpartum: open-label trial of quetiapine augmentation.
J Clin Psychopharmacol.
2004;
24
624-627
MissingFormLabel
- 68
Marazziti D, Consoli G.
Treatment strategies for obsessive-compulsive disorder.
Exp Opin Pharmacother.
2010;
11
331-343
MissingFormLabel
- 69
Tschudin S, Lapaire O.
Antidepressiva in der Schwangerschaft.
Therapeutische Umschau.
2005;
62
17-22
MissingFormLabel
- 70
Källen B A, Olausson P O.
Maternal use of selective reuptake inhibitors in early pregnancy and infant congenital
malformations.
Birth Defects Res A Clin Mol Teratol.
2007;
79
301-308
MissingFormLabel
- 71
Alwan S, Friedman J M.
Safety of selective serotonin reuptake inhibitors in pregnancy.
CNS Drugs.
2009;
23
493-509
MissingFormLabel
- 72
Tuccori M, Testi A, Antonioli L et al.
Safety concerns associated with the use of serotonin reuptake inhibitors and other
serotonergic/noradrenergic antidepressants during pregnancy: a review.
Clin Ther.
2009;
31
1426-1453
MissingFormLabel
- 73
Toh S, Mitchell A A, Loik C et al.
Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth
restriction.
J Clin Psychopharmacol.
2009;
29
555-560
MissingFormLabel
- 74
Källen B, Olausson P O.
Maternal use of selective serotonin reuptake inhibitors and persistent pulmonary hypertension
of the newborn.
Pharmacoepidemiol Drug Saf.
2008;
17
801-806
MissingFormLabel
- 75
Warburton W, Hertzman C, Oberlander T F.
A register study of the impact of stopping third trimester selective serotonin reuptake
inhibitor exposure on neonatal health.
Acta Psychiatr Scand.
2010;
121
471-479
MissingFormLabel
- 76
Nulman I, Rovet J, Stewart D E et al.
Child development following exposure to tricyclic antidepressants or fluoxetine throughout
fetal life: a prospective, controlled study.
Am J Psychiatry.
2002;
159
1889-1895
MissingFormLabel
- 77
Iqbal M M, Sobhan T, Aftab S R et al.
Diazepam use during pregnancy: A review of the literature.
Del Med Jrl.
2002;
74
127-134
MissingFormLabel
- 78
Freeman M P.
Breastfeeding and antidepressants: Clinical dilemmas and expert perspectives.
J Clinic Psychiatry.
2009;
70
291-292
MissingFormLabel
Dr. Paraskevi Mavrogiorgou
Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, LWL-Universitätsklinikum
Alexandrinenstr.1
44791 Bochum
eMail: paraskevi.mavrogiorgou-juckel@wkp-lwl.org