Die Neuropsychologie der nigrostriatalen dopaminergen Transmission am Beispiel des Morbus Parkinson

Zusammenfassung

Über kortiko-subkortiko-kortikale Schleifensysteme beeinflusst die dopaminerge Modulation auf der Ebene des Striatums nicht nur motorische Funktionen, sondern auch andere kortikale Efferenzen. Es wird eine Übersicht über neuropsychologische Befunde bei Morbus Parkinson gegeben und versucht, diese systemphysiologisch zu interpretieren. Die Theorie des „supervisory attentional system“ von Norman und Shallice (1986) erscheint geeignet, die Rolle von frontalem Kortex und Basalganglien in der Handlungssteuerung zu erklären.

Abstract

Through cortico-subcortico-cortical loop systems, the dopaminergic modulation influences not only motor, but also other executive functions. Neurospychological findings in Parkinson’s disease are reviewed and physiologically interpreted. The theory of a 'supervisory attentional system” according to Norman and Shallice (1986) seems to be an adequate model of the interaction of cortex and basal ganglia in executive function and control.

Schlüsselwörter

Morbus Parkinson - Neuropsychologie - Systemphysiologie

Keywords

Parkinson’s disease - neuropsychology - system physiology

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