Klin Padiatr 2011; 223(5): 299-307
DOI: 10.1055/s-0031-1280750
Report

© Georg Thieme Verlag KG Stuttgart · New York

The 2010 Guidelines on Neonatal Resuscitation (AHA, ERC, ILCOR): Similarities and Differences – What Progress Has Been Made since 2005?

Kommentar zu den Reanimationsrichtlinien 2010 für Neugeborene (AHA, ERC und ILCOR)C. C. Roehr1 , G. Hansmann2 , T. Hoehn3 , C. Bührer1
  • 1Department of Neonatology, Charité University Medical Center, Berlin, Germany
  • 2Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, USA
  • 3Department of General Paediatrics, University Medical Center, Düsseldorf, Germany
Further Information

Publication History

Publication Date:
03 August 2011 (online)

Abstract

In 2010, the American Heart Association (AHA), the European Resuscitation Council (ERC) and the International Liaison Committee on Resuscitation (ILCOR) issued new guidelines on newborn resuscitation. The new recommendations include: (1) pulse-oximetry for patient assessment during newborn resuscitation; (2) to start resuscitation of term infants with an FiO2 of 0.21; (3) cardio-respiratory resuscitation with a 3:1 chest compression/inflation ratio for a heart rate <60 beats/min; (4) regarding infants born from meconium stained amniotic fluid: no recommendation is given to suction the upper airways at the perineum (when the head is born), but it is recommended to inspect the oropharynx and trachea for obstruction and suction the lower airway before inflations are given when the infant is depressed; (5) for birth asphyxia in term or near term infants, to induce hypothermia (33.5–34.5°C) within 6 h after birth. AHA, ERC and ILCOR used nearly identical literature for their evidence evaluation process. While the AHA and ILCOR guidelines are almost identical, the ERC guidelines differ slightly from the latter with regards to (i) promoting sustained inflations at birth, (ii) promoting a wider range in applied inflations during resuscitation, and (iii) to suction the airways in infants born from meconium stained amniotic fluid, before inflations are given.

Zusammenfassung

Die American Heart Association (AHA), die European Resuscitation Council (ERC) und das International Liaison Committee on Resuscitation (ILCOR) veröffentlichten im Oktober 2010 die aktualisierten Fassungen ihrer jeweiligen Richtlinien für die Reanimation von Neugeborenen. Die neuen Richtlinien beinhalten den Einsatz von (1) Pulsoxymetrie zur Beurteilung des deprimierten Neugeborenen während der Erstversorgung; (2) einem initialen Atemgas ohne O2-Zumischung (FiO2 0,21) bei Reifgeborenen; (3) einem kardialen Kompressions- zu Ventilationsverhältnis von 3:1 bei persistierend niedriger Herzfrequenz <60/min; (4) bez. mekoniumhaltigen Fruchtwassers: keine Empfehlung für oder wider das intratracheale Absaugen bei Geburt des Kopfes (am Perineum) und beim deprimierten Kind die Inspektion zum Ausschluss von Verlegung des Orophyarynx und der tieferen Atemwege durch Mekonium sowie ggf. Absaugen dessen, bevor Atemunterstützung gegeben wird; (5) die Abkühlung der Körperkerntemperatur auf 33,5–34,5°C innerhalb der ersten 6h bei Geburtsasphyxie reifer oder annähernd reifer Neugeborener. Die AHA, ERC und ILCOR geben annähernd identische Textquellen zur Begründung ihrer Empfehlungen an. Die Empfehlungen der AHA und ILCOR sind annähernd identisch, die ERC-Empfehlungen weichen allerdings geringfügig von diesen beiden ab: Der ERC empfiehlt (i) prolongierte Inspirationszeiten während der ersten Atemhübe, (ii) einen breiteren Zielbereich an Atemfrequenzen in der Wiederbelebung und (iii) das konsequente Absaugen der Atemwege im Falle von mekoniumhaltigem Fruchtwasser.

References

  • 1 American Heart Association, American Academy of Pediatrics . 2005 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC) of pediatric and neonatal patients: neonatal resuscitation guidelines.  Pediatrics. 2006;  117 e978-e988
  • 2 Arbeitsgruppe der Schweizer Gesellschaft für Neonatologie . Empfehlungen zur Betreuung von Frühgeborenen an der Grenze der Lebensfähigkeit.  (Gestationsalter 22–26 SSW) Swiss Med J. 2002;  83 1589-1595
  • 3 Aziz HF, Martin JB, Moore JJ. The pediatric disposable end-tidal carbon dioxide detector role in endotracheal intubation in newborns.  J Perinatol. 1999;  19 110-113
  • 4 Azzopardi DV, Strohm B, Edwards AD. et al TOBY Study Group . Moderate hypothermia to treat perinatal asphyxial encephalopathy.  N Engl J Med. 2009;  361 1349-1358
  • 5 Bar-Joseph G, Abramson NS, Kelsey SF. et al . Improved resuscitation outcome in emergency medical systems with increased usage of sodium bicarbonate during cardiopulmonary resuscitation.  Acta Anaesthesiol Scand. 2005;  49 6-15
  • 6 Bell EF, Zumbach DK. The tiniest babies: a registry of survivors with birth weight less than 400 grams.  Pediatrics. 2011;  127 58-61
  • 7 Bennett S, Finer NN, Rich W. A comparison of three neonatal resuscitation devices.  Resuscitation. 2005;  67 113-118
  • 8 Beveridge CJ, Wilkinson AR. Sodium bicarbonate infusion during resuscitation of infants at birth.  Cochrane Database Syst Rev. 2006;  CD00486
  • 9 Carlo WA, Finer NN, Walsh MC. et al . Target ranges of oxygen saturation in extremely preterm infants.  N Engl J Med. 2010;  362 1959-1969
  • 10 Cramer K, Wiebe N, Hartling L. et al . Heat loss prevention: a systematic review of occlusive skin wrap for premature neonates.  J Perinatol. 2005;  25 763-769
  • 11 Dawson JA, Davis PG, O’Donnell CP. et al . Pulse oximetry for monitoring infants in the delivery room: a review.  Arch Dis Child Fetal Neonatal Ed. 2007;  92 F4-F7
  • 12 Dawson JA, Kamlin CO, Vento M. et al . Defining the reference range for oxygen saturation for infants after birth.  Pediatrics. 2010;  125 e1340-e1347
  • 13 Dawson JA, Schmölzer GM, Kamlin CO. et al . Oxygenation with T-piece versus self-inflating bag for ventilation of extremely preterm infants at birth: a randomized controlled trial.  J Pediatr. 2011;  158 912.e2-918.e2
  • 14 Edwards AD, Brocklehurst P, Gunn AJ. et al . Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data.  BMJ. 2010;  340 c363
  • 15 Eicher DJ, Wagner CL, Katikaneni LP. et al . Moderate hypothermia in neonatal encephalopathy: efficacy outcomes.  Pediatr Neurol. 2005;  32 11-17
  • 16 Finer NF. For the SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network.  N Engl J Med. 2010;  362 1970-1979
  • 17 Garey DM, Ward R, Rich W. et al . Tidal volume threshold for colorimetric carbon dioxide detectors available for use in neonates.  Pediatrics. 2008;  121 e1524-e1527
  • 18 Gluckman PD, Wyatt JS, Azzopardi D. et al . Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial.  Lancet. 2005;  365 663-670
  • 19 Guyatt GH, Oxman AD, Vist GE. et al . GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.  BMJ. 2008;  336 924-926
  • 20 Hansmann G. Neonatal resuscitation on air: it is time to turn down the oxygen tanks [Corrected].  Lancet. 2004;  364 1293-1294
  • 21 Hansmann G, Humpl T, Zimmermann A. ILCOR's new resuscitation guidelines in preterm and term infants: critical discussion and suggestions for implementation.  Klin Padiatr. 2007;  219 50-57
  • 22 Hazinski MF, Nolan JP, Billi JE. et al . Part 1: Executive summary: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations.  Circulation. 2010;  122 S250-S275
  • 23 Hosono S, Mugishima H, Fujita H. et al . Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks’ gestation: a randomised controlled trial.  Arch Dis Child Fetal Neonatal Ed. 2008;  93 F14-F19
  • 24 http://www.nichd.nih.gov/about/org/cdbpm/pp/prog_epbo/epbo_case.cfm (last accessed 24 Feb 2011)
  • 25 Hutton EK, Hassan ES. Late vs. early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials.  JAMA. 2007;  297 1241-1252
  • 26 Kattwinkel J, Perlman JM, Aziz K. et al . Part 15: neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.  Circulation. 2010;  122 S909-S919
  • 27 Kattwinkel J, Perlman J. The Neonatal Resuscitation Program: The evidence evaluation process and anticipating edition 6.  NeoReviews. 2010;  11 e673-e680
  • 28 Kelm M, Proquitté H, Schmalisch G. et al . Reliability of two common PEEP-generating devices used in neonatal resuscitation.  Klin Padiatr. 2009;  221 415-418
  • 29 Lin ZL, Yu HM, Lin J. et al . Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit.  J Perinatol. 2006;  26 180-184
  • 30 Lindner W, Högel J, Pohlandt F. Sustained pressure-controlled inflation or intermittent mandatory ventilation in preterm infants in the delivery room? A randomized, controlled trial on initial respiratory support via nasopharyngeal tube.  Acta Paediatr. 2005;  94 303-309
  • 31 Lindner W, Vossbeck S, Hummler H. et al . Delivery room management of extremely low birth weight infants: spontaneous breathing or intubation?.  Pediatrics. 1999;  103 961-967
  • 32 Lokesh L, Kumar P, Murki S. et al . A randomized controlled trial of sodium bicarbonate in neonatal resuscitation–effect on immediate outcome.  Resuscitation. 2004;  60 219-223
  • 33 Lopez-Herce J, Fernandez B, Urbano J. et al . Hemodynamic, respiratory, and perfusion parameters during asphyxia, resuscitation, and post-resuscitation in a pediatric model of cardiac arrest.  Intensive Care Med. 2011;  37 147-155
  • 34 Mariani G, Dik PB, Ezquer A. et al . Pre-ductal and post-ductal O2 saturation in healthy term neonates after birth.  J Pediatr. 2007;  150 418-421
  • 35 Marlow N, Wolke D, Bracewell MA. et al . EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth.  N Engl J Med. 2005;  352 9-19
  • 36 Moriette G, Rameix S, Azria E. et al . Naissances très prématurées: dilemmes et propositions de prise en charge. Seconde partie: enjeux éthiques, principes de prise en charge et recommandations.  Arch Pédiatr. 2010;  17 527-539
  • 37 Morley CJ, Dawson JA, Stewart MJ. et al . The effect of a PEEP valve on a Laerdal neonatal self-inflating resuscitation bag.  J Paediatr Child Health. 2010;  46 51-56
  • 38 O’Donnell CP, Kamlin CO, Davis PG. Clinical assessment of infant colour at delivery.  Arch Dis Child Fetal Neonatal Ed. 2007;  92 F465-F467
  • 39 Österreichische Gesellschaft für Kinder- und Jugendheilkunde . Erstversorgung von Frühgeborenen an der Grenze der Lebensfähigkeit.  Monatsschr Kinderheilkd. 2005;  7 711-715
  • 40 Perlman JM, Wyllie J, Kattwinkel J. et al . Part 11: neonatal resuscitation: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations.  Circulation. 2010;  122 S516-S538
  • 41 Pignotti MS, Moratti S. Regulation of treatment of infants at the edge of viability in Italy: the role of the medical profession?.  J Med Ethics. 2010;  36 795-797
  • 42 Pignotti MS, Moratti S. The Italian Ministry of Health recommends resuscitation for all preterm infants irrespective of gestational age and parental consent.  Arch Dis Child Fetal Neonatal Ed. 2010;  95 F150-F151
  • 43 Pignotti MS. Extremely preterm births: recommendations for treatment in European countries.  Arch Dis Child Fetal Neonatal Ed. 2008;  93 F403-F406
  • 44 Pohlandt F. Gemeinsame Empfehlung der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe, Deutschen Gesellschaft für Kinderheilkunde und Jugendmedizin, Deutschen Gesellschaft für Perinatale Medizin und Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin. Premature Birth at the Boundary of Infant Viability.  Z Geburtshilfe Neonatol. 2008;  212 109-113
  • 45 Rabe H, Reynolds G, Diaz-Rossello J. A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants.  Neonatology. 2008;  93 138-144
  • 46 Rabe H, Jewison A, Alvarez RF. et al . Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial.  Obstet Gynecol. 2011;  117 205-211
  • 47 Raupp P, McCutcheon C. Neonatal resuscitation – an analysis of the transatlantic divide.  Resuscitation. 2007;  75 345-349
  • 48 Repetto JE, Donohue PA-C PK, Baker SF. et al . Use of capnography in the delivery room for assessment of endotracheal tube placement.  J Perinatol. 2001;  21 284-287
  • 49 Richmond S, Wyllie J. European Resuscitation Council Guidelines for Resuscitation 2010 Section 7. Resuscitation of babies at birth.  Resuscitation. 2010;  81 1389-1399
  • 50 Roberts WA, Maniscalco WM, Cohen AR. et al . The use of capnography for recognition of esophageal intubation in the neonatal intensive care unit.  Pediatr Pulmonol. 1995;  19 262-268
  • 51 Roehr CC, Kelm M, Fischer HS. et al . Manual ventilation devices in neonatal resuscitation: tidal volume and positive pressure-provision.  Resuscitation. 2010;  81 202-205
  • 52 Saugstad OD, Aune D. In search of the optimal oxygen saturation for extremely low birth weight infants: A systematic review and meta-analysis.  Neonatology. 2010;  100 1-8
  • 53 Salhab WA, Wyckoff MH, Laptook AR. et al . Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia.  Pediatrics. 2004;  114 361-366
  • 54 Schmölzer GM, Poulton DA, Dawson JA. et al . Assessment of flow waves and colorimetric CO2 detector for endotracheal tube placement during neonatal resuscitation.  Resuscitation. 2011;  82 307-312
  • 55 Shankaran S, Laptook AR, Ehrenkranz RA. et al . Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.  N Engl J Med. 2005;  353 1574-1584
  • 56 Singh A, Duckett J, Newton T. et al . Improving neonatal unit admission temperatures in preterm babies: exothermic mattresses, polythene bags or a traditional approach?.  J Perinatol. 2010;  30 45-49
  • 57 Synnes AR, Chien LY, Peliowski A. et al . Variations in intraventricular hemorrhage incidence rates among Canadian neonatal intensive care units.  J Pediatr. 2001;  138 525-531
  • 58 Tan A, Schulze A, O’Donnell CP. et al . Air versus oxygen for resuscitation of infants at birth.  Cochrane Database Syst Rev. 2005;  18 CD002273
  • 59 tePas AB, Walther FJ. A randomized, controlled trial of delivery-room respiratory management in very preterm infants.  Pediatrics. 2007;  120 322-329
  • 60 Tyson JE, Parikh NA, Langer J. et al . National Institute of Child Health and Human Development Neonatal Research Network. Intensive care for extreme prematurity – moving beyond gestational age.  N Engl J Med. 2008;  358 1672-1681
  • 61 Vain NE, Szyld EG, Prudent LM. et al . Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: multicentre, randomised controlled trial.  Lancet. 2004;  364 597-602
  • 62 Vento M, Moro M, Escrig R. et al . Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease.  Pediatrics. 2009;  124 e439-e449
  • 63 Vohra S, Roberts RS, Zhang B. et al . Heat Loss Prevention (HeLP) in the delivery room: a randomized controlled trial of polyethylene occlusive skin wrapping in very preterm infants.  J Pediatr. 2004;  145 750-753
  • 64 Voogdt KG, Morrison AC, Wood FE. et al . A randomised, simulated study assessing auscultation of heart rate at birth.  Resuscitation. 2010;  81 1000-1003
  • 65 Salhab WA, Wyckoff MH, Laptook AR. et al . Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia.  Pediatrics. 2004;  114 361-366
  • 66 Wang CL, Anderson C, Leone TA. et al . Resuscitation of preterm neonates by using room air or 100% oxygen.  Pediatrics. 2008;  121 1083-1089
  • 67 Wyckoff MH, Barber CA. Use and efficacy of endotracheal versus intravenous epinephrine during neonatal cardiopulmonary resuscitation in the delivery room.  Pediatrics. 2006;  118 1028-1034
  • 68 Wyckoff MH, Perlman JM. Use of high-dose epinephrine and sodium bicarbonate during neonatal resuscitation: is there proven benefit?.  Clin Perinatol. 2006;  33 141-151
  • 69 Wyllie J, Perlman JM, Kattwinkel J. et al . Part 11: Neonatal resuscitation: 2010 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations.  Resuscitation. 2010;  81 e260-e287

Correspondence

Dr. Charles Christoph RoehrM.D. 

Department of Neonatology

Charité Universitätsmedizin

Berlin

Charitéplatz 1

10117 Berlin

Germany

Phone: + 49/30/4505 160 52

Fax: + 49/30/4505 169 20

Email: christoph.roehr@charite.de

    >