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DOI: 10.1055/s-0031-1280338
© Georg Thieme Verlag KG Stuttgart · New York
Phosphodiesterase I-Inhibiting Diels-Alder Adducts from the Leaves of Morus mesozygia
Publication History
received May 29, 2011
revised Sept. 13, 2011
accepted October 11, 2011
Publication Date:
14 November 2011 (online)

Abstract
A new 2-arylbenzofuran derivative, (+)-dimethylsmoracin O (1), and three new Diels-Alder type adducts, mesozygins A–C (2–4), in addition to eight known compounds, artonin I (5), chalcomaracin (6), norartocarpetin (7), moracin L (8), mulberrofuran F (9), moracin M (10), moracin C (11), and morachalcone A (12), were isolated from the leaves of Morus mesozygia Stapf. Structures were elucidated by spectroscopic data analyses. Compounds 2–7 displayed a potent phosphodiesterase I inhibitory activity.
Key words
Morus mesozygia - Moraceae - Diels-Alder adducts - (+)-dimethylsmoracin O - mesozygins A–C - phosphodiesterase I inhibition
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Dr. Zulfiqar Ali
National Center for Natural Products Research
School of Pharmacy
University of Mississippi
University, MS 38677
USA
Phone: +1 66 29 15 78 61
Email: zulfiqar@olemiss.edu
Dr. Gilbert D. W. F. Kapche
Department of Chemistry
Higher Teacher Training College
University of Yaounde I
P. O. Box 47
Yaounde 237
Cameroon
Phone: +2 37 77 66 49 73
Email: dkapche2002@yahoo.com