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DOI: 10.1055/s-0031-1280320
© Georg Thieme Verlag KG Stuttgart · New York
Four New Dammarane-Type Triterpene Saponins from the Stems and Leaves of Panax ginseng and Their Cytotoxicity on HL-60 Cells
Publikationsverlauf
received July 30, 2011
revised October 8, 2011
accepted October 12, 2011
Publikationsdatum:
27. Oktober 2011 (online)

Abstract
Four new triterpene saponins, ginsenosides Rh14-Rh17 (1–4), along with two known compounds, 20(S)-ginsenoside Rg2 and dammar-(E)-20(22),24-diene-3β,6α,12β-triol, were isolated from the stems and leaves of Panax ginseng. The structures of the new compounds were elucidated as 3β,6α,12β,24ξ-tetrahydroxy-dammar-(E)-20(22),25-diene 6-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (1), 3β,12β,24ξ-trihydroxy-dammar-(E)-20(22),25-diene 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (2), 3β,6α,12β-trihydroxy-dammar-(E)-20(22),24-diene 3-O-β-D-glucopyranoside (3), and 3-oxo-6α,12β,20(S)-trihydroxy-dammar-24-ene 6-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (4) by means of extensive spectroscopic and chemical methods, respectively. The isolated compounds were tested for in vitro cytotoxicity against HL-60 cells.
Key words
Panax ginseng - Araliaceae - dammarane triterpenoids - saponin - cytotoxicity - HL-60
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Prof. Xiu-Wei Yang
State Key Laboratory of Natural and Biomimetic Drugs (Peking University)
School of Pharmaceutical Sciences
Peking University Health Science Center
38 Xueyuan Road, Haidian District
100191 Beijing
P. R. China
Telefon: +86 10 82 80 51 06
Fax: +86 10 82 80 27 24
eMail: xwyang@bjmu.edu.cn