Abstract
The phytochemical investigation of the ethanolic extract of the whole plants of Geum japonicum Thunb. var. chinense F. Bolle yielded four new compounds: 20β,28-epoxy-28-hydroxytaraxasteran-3β-ol (1), (7R,8R)-4-hydroxy-9′-O-(α-L-rhamnopyranosyl)-3,3′,5′-trimethoxy-8-O-4′-neolignan (2), (7R,8S)-4-hydroxy-9′-O-(α-L-rhamnopyranosyl)-3,3′,5′-trimethoxy-8-O-4′-neolignan (3), and (7S,8S)-5-methoxycupressoside A (4), as well as 40 other known compounds. Structures were elucidated by physical, chemical, and spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The taraxasterane-type triterpene (1) and lignans (2–6) are reported for the first time from the Geum genus. Moreover, all compounds were evaluated for anti-inflammatory activities against NO production in RAW264.7 macrophages, and only moderate activities were detected.
Key words
Geum japonicum Thunb. var. chinense F. Bolle - Rosaceae - taraxasterane-type triterpene - lignans - anti-inflammatory activity
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Huizi Jin
School of Pharmacy
Shanghai Jiao Tong University
Min Hang Dong Chuan Rd 800
Shanghai 200240
P. R. China
Telefon: +86 21 34 20 59 89
Fax: +86 21 34 20 59 89
eMail: kimhz@sjtu.edu.cn
Weidong Zhang
School of Pharmacy
Shanghai Jiao Tong University
Min Hang Dong Chuan Rd 800
Shanghai 200240
P. R. China
Telefon: +86 21 34 20 59 89
Fax: +86 21 34 20 59 89
eMail: wdzhangy@hotmail.com