Abstract
Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1–10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NMR techniques along with IR and HR-TOF-MS. Rogchaponins R4 (4) and R5 (5) showed inhibitory activities against yeast alcohol dehydrogenase (ADH) with IC50 values of 16.1 ± 3.2 and 15.4 ± 3.3 µM, respectively. A 4-methylpyrazole positive control exhibited an IC50 of 2750 ± 50 µM. However, the saponins showed no inhibitory activity against yeast aldehyde dehydrogenase (ALDH).
Key words
tea root -
Camellia sinensis
- Theaceae - triterpenoid saponin - rogchaponin - alcohol dehydrogenase
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Prof. Dr. Surk-Sik Moon
Department of Chemistry
Kongju National University
Gongju 314-701
Republic of Korea
Telefon: +82 4 18 50 84 95
Fax: +82 4 18 50 84 79
eMail: ssmoon@kongju.ac.kr
