Fetal Programming of Adipose Tissue: Effects of Intrauterine Growth Restriction and Maternal Obesity/High-Fat Diet

Mina Desai; Michael G Ross

doi:10.1055/s-0031-1275517

Seminars in Reproductive Medicine, Table of Contents

Semin Reprod Med 2011; 29(3): 237-245
DOI: 10.1055/s-0031-1275517

Fetal Programming of Adipose Tissue: Effects of Intrauterine Growth Restriction and Maternal Obesity/High-Fat Diet

Mina Desai¹ ^, ² , Michael G. Ross¹ ^, ²

¹Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
²Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California

Abstract

ABSTRACT

A newly recognized primary cause of obesity epidemic is the developmental programming effects of (1) intrauterine growth-restricted (IUGR) newborns exposed in utero to undernutrition, and (2) normal or excessive weight newborns exposed to maternal obesity and high-fat (HF) diets. The mechanisms contributing to offspring obesity have been extensively studied in animal models with adipose tissue identified as one of the principal targets of programming. IUGR and HF offspring exhibit programmed adipocytes, such that an intrinsic enhanced lipogenesis and adipocyte proliferation contribute to the development of obesity. This is attributed to early induction of adipogenic transcription factor peroxisome proliferator-activated receptor (PPAR)γ, whose activity is enhanced under limited or excess nutrient availability. Nonetheless, this occurs via different mechanisms involving PPARγ coregulators: In IUGR, it is upregulation of coactivators, whereas in HF newborns, it is downregulation of corepressors. Thus preventive therapeutic interventions will require target-specific modalities that depend on the primary etiology.

KEYWORDS

Adipogenesis - lipogenesis - PPARγ - obesity

Full Text

References

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